(S)-(4-(Prop-1-en-2-yl)cyclohex-1-enyl)methanol Substituted Phthalocyanines: Synthesis, Photochemical and Photophysical Properties, and Enzyme Inhibition Behaviors

IF 3.7 2区 化学 Q2 CHEMISTRY, APPLIED
Tenzile Alagöz, Ahmet T.Bilgiçli, Wiem Marzouk, Eda Mehtap Özden, Armağan Günsel, İlhami Gülçin, Meryem N. Yarasir, Hayriye Genc Bilgicli
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引用次数: 0

Abstract

In this study, (S)-4-((4-(prop-1-en-2-yl)cyclohex-1-enyl)methoxy)phthalonitrile, as a novel phthalonitrile derivative, which is the starting material for phthalocyanine synthesis, was prepared and characterized. Then, its symmetric metal-free [H2Pc (2)] and metallophthalocyanine derivatives [ZnPc (3), CuPc (4), and CoPc (5)] were successfully synthesized, and their structures were characterized with the combination of suitable spectroscopic methods. The solubility and aggregation properties of novel phthalocyanines were investigated. Also, the photophysical and photochemical properties of the newly synthesized H2Pc (2) and ZnPc (3) were studied in solution media. The singlet oxygen quantum values are 0.45 for H2Pc (2) and 0.75 for ZnPc (3). According to these results, the peripheral perillyl alcohol substitution of phthalocyanines increased the therapeutic efficacy. At the same time, the newly synthesized phthalocyanines (25) displayed the strongest inhibitory effect. The results indicate a high affinity and selectivity for carbonic anhydrases. This underscores their potential as promising lead compounds for developing therapeutic agents to treat conditions such as glaucoma, epilepsy, and certain types of cancer.

(S)-(4-(prop -1-en-2基)环己基-1-烯基)甲醇取代酞菁:合成、光化学和光物理性质及酶抑制行为
本研究制备了(S)-4-((4-(丙-1-烯-2基)环己基-1-烯基)甲氧基)邻苯二腈,作为一种新型的邻苯二腈衍生物,是合成酞菁的起始原料。然后,成功合成了其对称无金属[H2Pc(2)]和金属酞菁衍生物[ZnPc (3), CuPc (4), CoPc(5)],并结合合适的光谱方法对其结构进行了表征。研究了新型酞菁的溶解度和聚集性。并对新合成的H2Pc(2)和ZnPc(3)在溶液介质中的光物理和光化学性质进行了研究。H2Pc(2)和ZnPc(3)的单重态氧量子值分别为0.45和0.75。根据这些结果,外周紫苏醇取代酞菁可提高治疗效果。同时,新合成的酞菁(2-5)表现出最强的抑制作用。结果表明,该化合物对碳酸酐酶具有较高的亲和力和选择性。这强调了它们作为开发治疗药物的先导化合物的潜力,用于治疗青光眼、癫痫和某些类型的癌症。
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来源期刊
Applied Organometallic Chemistry
Applied Organometallic Chemistry 化学-无机化学与核化学
CiteScore
7.80
自引率
10.30%
发文量
408
审稿时长
2.2 months
期刊介绍: All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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