Tenzile Alagöz, Ahmet T.Bilgiçli, Wiem Marzouk, Eda Mehtap Özden, Armağan Günsel, İlhami Gülçin, Meryem N. Yarasir, Hayriye Genc Bilgicli
{"title":"(S)-(4-(Prop-1-en-2-yl)cyclohex-1-enyl)methanol Substituted Phthalocyanines: Synthesis, Photochemical and Photophysical Properties, and Enzyme Inhibition Behaviors","authors":"Tenzile Alagöz, Ahmet T.Bilgiçli, Wiem Marzouk, Eda Mehtap Özden, Armağan Günsel, İlhami Gülçin, Meryem N. Yarasir, Hayriye Genc Bilgicli","doi":"10.1002/aoc.70378","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>In this study, (S)-4-((4-(prop-1-en-2-yl)cyclohex-1-enyl)methoxy)phthalonitrile, as a novel phthalonitrile derivative, which is the starting material for phthalocyanine synthesis, was prepared and characterized. Then, its symmetric metal-free [H<sub>2</sub>Pc (<b>2</b>)] and metallophthalocyanine derivatives [ZnPc (<b>3</b>), CuPc (<b>4</b>), and CoPc (<b>5</b>)] were successfully synthesized, and their structures were characterized with the combination of suitable spectroscopic methods. The solubility and aggregation properties of novel phthalocyanines were investigated. Also, the photophysical and photochemical properties of the newly synthesized H<sub>2</sub>Pc (<b>2</b>) and ZnPc (<b>3</b>) were studied in solution media. The singlet oxygen quantum values are 0.45 for H<sub>2</sub>Pc (<b>2</b>) and 0.75 for ZnPc (<b>3</b>). According to these results, the peripheral perillyl alcohol substitution of phthalocyanines increased the therapeutic efficacy. At the same time, the newly synthesized phthalocyanines (<b>2</b>–<b>5</b>) displayed the strongest inhibitory effect. The results indicate a high affinity and selectivity for carbonic anhydrases. This underscores their potential as promising lead compounds for developing therapeutic agents to treat conditions such as glaucoma, epilepsy, and certain types of cancer.</p>\n </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 10","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Organometallic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aoc.70378","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, (S)-4-((4-(prop-1-en-2-yl)cyclohex-1-enyl)methoxy)phthalonitrile, as a novel phthalonitrile derivative, which is the starting material for phthalocyanine synthesis, was prepared and characterized. Then, its symmetric metal-free [H2Pc (2)] and metallophthalocyanine derivatives [ZnPc (3), CuPc (4), and CoPc (5)] were successfully synthesized, and their structures were characterized with the combination of suitable spectroscopic methods. The solubility and aggregation properties of novel phthalocyanines were investigated. Also, the photophysical and photochemical properties of the newly synthesized H2Pc (2) and ZnPc (3) were studied in solution media. The singlet oxygen quantum values are 0.45 for H2Pc (2) and 0.75 for ZnPc (3). According to these results, the peripheral perillyl alcohol substitution of phthalocyanines increased the therapeutic efficacy. At the same time, the newly synthesized phthalocyanines (2–5) displayed the strongest inhibitory effect. The results indicate a high affinity and selectivity for carbonic anhydrases. This underscores their potential as promising lead compounds for developing therapeutic agents to treat conditions such as glaucoma, epilepsy, and certain types of cancer.
期刊介绍:
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.