Systemic Immune-Inflammation Index and Neutrophil-To-Lymphocyte Ratio: U-Shaped Association With Overactive Bladder

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY

LUTS: Lower Urinary Tract Symptoms Pub Date : 2025-09-03 DOI:10.1111/luts.70029

Qinglong Yang, Haolin Chen, Hanyuan Lin, Haoxian Tang, Nan Luo, Xuan Zhang, Jingtao Huang, Xuxia Sui, Qingtao Yang

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引用次数: 0

Abstract

Objectives

This study aims to examine the association of systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) with the prevalence of overactive bladder (OAB).

Methods

This cross-sectional study analyzed data from 22,343 participants (≥ 20 years) in the National Health and Nutrition Examination Survey (2005–2018). We applied weighted multivariate logistic regression, restricted cubic spline (RCS) regression, subgroup, and sensitivity analyses to assess the associations between SII, NLR, and OAB.

Results

RCS analysis revealed U-shaped relationships with inflection points at 6.13 for ln(SII) and 0.65 for ln(NLR). In the fully adjusted model, ln(SII) ≤ 6.13 showed a negative correlation with OAB (OR = 0.83; 95% CI: 0.70–0.99), while ln(SII) > 6.13 was positively correlated (OR = 1.32; 95% CI: 1.10–1.58). Similarly, ln(NLR) > 0.65 correlated positively with OAB (OR = 1.40; 95% CI: 1.16–1.71). Subgroup analyses revealed significant differences in alcohol use subgroups for ln(SII) ≤ 6.13 and ln(NLR) ≤ 0.65 (P for interaction < 0.05).

Conclusions

SII and NLR may serve as biomarkers for assessing OAB risk.

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全身免疫炎症指数和中性粒细胞与淋巴细胞比值：u型与膀胱过度活跃的关系

目的探讨全身免疫炎症指数（SII）和中性粒细胞与淋巴细胞比值（NLR）与膀胱过动症（OAB）患病率的关系。方法本横断面研究分析了2005-2018年全国健康与营养检查调查中22343名参与者（≥20岁）的数据。我们应用加权多元逻辑回归、限制性三次样条（RCS）回归、亚组和敏感性分析来评估SII、NLR和OAB之间的关系。结果RCS分析显示，ln（SII）和ln（NLR）与拐点呈u型关系，分别为6.13和0.65。在完全调整模型中，ln(SII)≤6.13与OAB呈负相关（OR = 0.83, 95% CI: 0.70-0.99）， ln(SII) >； 6.13呈正相关（OR = 1.32, 95% CI: 1.10-1.58）。同样，ln(NLR) >； 0.65与OAB呈正相关（OR = 1.40; 95% CI: 1.16-1.71）。亚组分析显示，在ln(SII)≤6.13和ln(NLR)≤0.65时，酒精使用亚组间存在显著差异（相互作用P < 0.05）。结论SII和NLR可作为评估OAB风险的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

LUTS: Lower Urinary Tract Symptoms UROLOGY & NEPHROLOGY-

CiteScore

3.00

自引率

7.70%

发文量

审稿时长

>12 weeks

期刊介绍： LUTS is designed for the timely communication of peer-reviewed studies which provides new clinical and basic science information to physicians and researchers in the field of neurourology, urodynamics and urogynecology. Contributions are reviewed and selected by a group of distinguished referees from around the world, some of whom constitute the journal''s Editorial Board. The journal covers both basic and clinical research on lower urinary tract dysfunctions (LUTD), such as overactive bladder (OAB), detrusor underactivity, benign prostatic hyperplasia (BPH), bladder outlet obstruction (BOO), urinary incontinence, pelvic organ prolapse (POP), painful bladder syndrome (PBS), as well as on other relevant conditions. Case reports are published only if new findings are provided. LUTS is an official journal of the Japanese Continence Society, the Korean Continence Society, and the Taiwanese Continence Society. Submission of papers from all countries are welcome. LUTS has been accepted into Science Citation Index Expanded (SCIE) with a 2011 Impact Factor.