Systemic Transthyretin Amyloidosis Incidentally Diagnosed With Prostate Biopsy: A Case Report

Q4 Medicine

IJU Case Reports Pub Date : 2025-08-01 DOI:10.1002/iju5.70079

Michihide Nakamura, Shinnosuke Kuroda, Takashi Kawahara, Erika Muraoka, Genya Iwamoto, Kota Shimokihara, Takeaki Noguchi, Masanobu Yamazaki, Akihito Hashizume, Daiji Takamoto, Rie Horii, Satoshi Fujii, Miki Tanoshima, Junichi Teranishi, Hiroji Uemura

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Abstract

Introduction

The diagnosis of systemic transthyretin amyloidosis based on prostate biopsy is very rare, and we report this case with a literature review.

Case Presentation

A 73-year-old male patient was referred to our department due to an increased serum prostate-specific antigen level at 10.4 ng/mL while receiving benign prostatic hypertrophy treatment. Prostate needle biopsy was performed, and the pathology revealed transthyretin amyloid deposits in the prostate tissue without adenocarcinoma. Subsequent 99mTc pyrophosphate scintigraphy confirmed the accumulation in the myocardium. The patient was diagnosed with cardiac transthyretin amyloidosis.

Conclusion

Amyloidosis is a systemic disease where amyloid is deposited in multiple organs, causing various dysfunctions. Considering both our case and previous reports, prostatic amyloidosis may frequently be associated with systemic involvement. The treatments including oligonucleotide therapeutic agents and transthyretin-stabilizing drugs will be more effective with early diagnosis and early treatment, and various symptoms suspicious of systemic amyloidosis should not be missed.

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前列腺活检偶然诊断的全身性甲状腺转蛋白淀粉样变1例报告

基于前列腺活检的全身性甲状腺转蛋白淀粉样变的诊断是非常罕见的，我们报告这个病例并进行文献复习。一例73岁男性患者在接受良性前列腺肥大治疗时血清前列腺特异性抗原升高至10.4 ng/mL，转介至我科。行前列腺穿刺活检，病理显示甲状腺素淀粉样蛋白沉积于前列腺组织，无腺癌。随后的99mTc焦磷酸盐显像证实了心肌的蓄积。患者被诊断为心脏转甲状腺蛋白淀粉样变。结论淀粉样变性是一种淀粉样蛋白沉积于多器官的全身性疾病，可引起多种功能障碍。考虑到我们的病例和以前的报告，前列腺淀粉样变可能经常与全身累及有关。早期诊断、早期治疗，采用寡核苷酸治疗药物、甲状腺素稳定药物等治疗更有效，各种怀疑全体性淀粉样变性的症状不可错过。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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