Reliability and Spatial Consistency of MR Diffusion Tensor Imaging Measures Along the Cerebral Perivascular Space

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2025-09-03 DOI:10.1111/jon.70086

Enchao Qiu, Joga Chaganti, Phillip Phan, Mahdi Alizadeh, Devon Middleton, Kiran Talekar, Prabath K. Mondel, Scott H. Faro, Feroze B. Mohamed, Hsiangkuo Yuan

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引用次数: 0

Abstract

Background and Purpose

Diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) has emerged as a promising noninvasive method for evaluating water motion that may reflect glymphatic system function. However, the reliability of DTI-ALPS measurements across different region-of-interest (ROI) selection methods remains underinvestigated. This study aimed to assess the interrater reliability among three neuroradiologists in native space and compare DTI-ALPS indices derived from ROIs placed in subjects’ native space versus standardized Montreal Neurological Institute (MNI) space.

Methods

DTI-ALPS indices from 16 healthy subjects were calculated from both left and right hemispheres using two ROI placement approaches: (1) native space ROIs manually placed by three neuroradiologists, and (2) standardized ROIs in MNI space based on the fractional anisotropy template. Interrater reliability was assessed using intraclass correlation coefficients (ICCs). The proportion of ROI overlaps among the three neuroradiologists was also evaluated. Differences between native and MNI space measurements were evaluated using related-samples Friedman's analysis with post hoc pairwise comparisons.

Results

Interrater reliability for native space ROI placement was moderate for left-sided DTI-ALPS indices (ICC = 0.599) and good for right-sided DTI-ALPS indices (ICC = 0.807). Spatial overlap analysis revealed poor Dice similarity coefficients across all ROI types (range: 0.047–0.312), with right association ROIs showing higher spatial consistency. Significant differences were found between native and MNI space measurements for left-sided DTI-ALPS indices (p = 0.002) but not for right-sided DTI-ALPS indices (p = 0.913).

Conclusion

These findings highlight the importance of standardized ROI selection approaches for clinical applications of DTI-ALPS.

Abstract Image

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脑血管周围MR弥散张量成像测量的可靠性和空间一致性

背景与目的沿血管周围间隙弥散张量成像分析（DTI-ALPS）已成为一种有前途的非侵入性方法，用于评估可能反映淋巴系统功能的水运动。然而，跨不同兴趣区域（ROI）选择方法的DTI-ALPS测量的可靠性仍未得到充分研究。本研究旨在评估三名神经放射学家在本地空间的互译可靠性，并比较由放置在受试者本地空间的roi得出的DTI-ALPS指数与标准化的蒙特利尔神经学研究所（MNI）空间。方法采用两种ROI放置方法(1)由3名神经放射科医生手动放置的原生空间ROI和(2)基于分数各向异性模板的MNI空间标准化ROI，从左、右半球计算16名健康受试者的DTI-ALPS指数。用类内相关系数（ICCs）评估组间信度。并对三位神经放射科医师的ROI重叠比例进行了评估。使用相关样本弗里德曼分析和事后两两比较来评估本地和MNI空间测量之间的差异。结果左侧DTI-ALPS指数对原生空间ROI放置的信度中等（ICC = 0.599），右侧DTI-ALPS指数的信度较好（ICC = 0.807）。空间重叠分析显示，所有ROI类型的Dice相似系数都很差（范围：0.047-0.312），右关联ROI表现出更高的空间一致性。本地和MNI空间测量在左侧DTI-ALPS指数上有显著差异（p = 0.002），而在右侧DTI-ALPS指数上无显著差异（p = 0.913）。结论标准化ROI选择方法对DTI-ALPS的临床应用具有重要意义。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!