Libman-Sacks endocarditis in pediatric systemic lupus erythematosus: A multicenter retrospective study

IF 2.2 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Archives of Cardiovascular Diseases Pub Date : 2025-09-01 DOI:10.1016/j.acvd.2025.06.029

Safia Essbai , Maelle Selegny , Berangere Urbina-Hiel , Elise Barre , Héloïse Reumaux , Isabelle Durand , Djamal-Dine Djeddi , Elise Daire

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引用次数: 0

Abstract

Introduction

Libman-Sacks endocarditis in pediatric systemic lupus erythematosus: a multicenter retrospective study.

Objective

To estimate the prevalence of LSE in pediatric SLE, describe its clinical and embolic features, identify associated risk factors, and evaluate therapeutic approaches.

Methods

We will conduct a multicenter retrospective cohort study including pediatric SLE patients diagnosed between 2006 and 2024 in three French centers (Lille, Rouen, Amiens). A nested case-control analysis will compare patients with LSE (cases) to those without valvular involvement (controls), matched on age and disease duration when feasible. Data collection is ongoing and includes clinical, immunological, and echocardiographic data, embolic events, corticosteroid resistance, and treatments. Associations will be assessed using odds ratios (ORs) with 95% confidence intervals.

Expected results

Among the 30 patients currently included, 5 have confirmed LSE. We expect to identify potential factors associated with LES such as antiphospholipid antibodies, active disease, and corticosteroid resistance. Detailed descriptions of embolic complications and variability in therapeutic strategies are also anticipated.

Perspectives

This study aims to raise awareness of LSE as a rare but serious complication in pediatric SLE. It may help identify lupus patients at risk of developing LSE in the pediatric population, and clarify cardiac lesions, complications, and therapeutic strategies in these patients.

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小儿系统性红斑狼疮的Libman-Sacks心内膜炎：一项多中心回顾性研究

儿童系统性红斑狼疮的libman - sacks心内膜炎：一项多中心回顾性研究。目的评估LSE在小儿SLE中的患病率，描述其临床和栓塞特征，识别相关危险因素，并评估治疗方法。方法：我们将在法国三个中心（里尔、鲁昂、亚眠）开展一项多中心回顾性队列研究，纳入2006年至2024年间诊断的小儿SLE患者。巢式病例-对照分析将LSE患者（病例）与无瓣膜受累患者（对照）进行比较，在可行的情况下，年龄和病程相匹配。数据收集正在进行中，包括临床、免疫学和超声心动图数据、栓塞事件、皮质类固醇抵抗和治疗。将使用95%置信区间的比值比（ORs）评估相关性。预期结果目前纳入的30例患者中，有5例已确诊LSE。我们希望确定与LES相关的潜在因素，如抗磷脂抗体、活动性疾病和皮质类固醇抵抗。栓塞并发症的详细描述和治疗策略的可变性也被期待。本研究旨在提高LSE作为小儿SLE罕见但严重并发症的认识。它可能有助于识别狼疮患者在儿童人群中发展为LSE的风险，并阐明这些患者的心脏病变，并发症和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Cardiovascular Diseases 医学-心血管系统

CiteScore

4.40

自引率

6.70%

发文量

审稿时长

34 days

期刊介绍： The Journal publishes original peer-reviewed clinical and research articles, epidemiological studies, new methodological clinical approaches, review articles and editorials. Topics covered include coronary artery and valve diseases, interventional and pediatric cardiology, cardiovascular surgery, cardiomyopathy and heart failure, arrhythmias and stimulation, cardiovascular imaging, vascular medicine and hypertension, epidemiology and risk factors, and large multicenter studies. Archives of Cardiovascular Diseases also publishes abstracts of papers presented at the annual sessions of the Journées Européennes de la Société Française de Cardiologie and the guidelines edited by the French Society of Cardiology.