The cellular epigenetic blueprint of plant regeneration

Abstract

Plants exhibit remarkable regenerative capacities, enabling tissue repair, de novo organogenesis, and somatic embryogenesis in response to mechanical injury or phytohormone induction. At the cellular level, this process is driven by the establishment of pluripotency and cell fate specification, regulated through dynamic epigenomic remodeling. Emerging studies have begun to unravel the intricate regulatory circuits governing regeneration in a cell-type- and lineage-specific manner. In this short review, we synthesize key findings from interconnected studies, exploring potential common mechanisms underlying the epigenetic regulation of plant regeneration. We also highlight promising research directions, emerging tools, and innovative strategies to investigate plant regeneration epigenetics at single-cell and single-cell-type resolution. These technological advances will provide critical insights into plant cell fate determination, the fundamental process governing regeneration.