Management of glyphosate poisoning with continuous renal replacement therapy (CRRT): A case report

Abstract

Glyphosate is a commonly used herbicide, and its toxicity is primarily due to the uncoupling of oxidative phosphorylation and polyoxymethylene amine (POEA) mediated cardiotoxicity. A 64-year-old was brought to the hospital with an alleged history of consumption of glyphosate. The patient has a known history of ischemic heart disease with a ejection fraction. ECG showed QT prolongation. Given the risk of metabolic acidosis and hyperkalemia, in the background of low cardiac output, continuous renal replacement therapy (CRRT) was initiated. The patient was hemodynamically stable after CRRT sessions and was discharged from the ICU. This case highlights the potential role of CRRT in managing glyphosate poisoning, particularly in patients with significant cardiac comorbidities.