Integration of inflammatory biomarkers and family counseling in postpartum depression management: A multidisciplinary perspective

Abstract

This correspondence responds to the recent publication by Xie et al. (2025) on immune-inflammatory biomarkers associated with postpartum depression (PPD). We commend the study's methodological rigor and highlight its implications for early detection. Integrating biological screening with psychosocial assessment is essential to address the multifactorial etiology of PPD. Drawing from multidisciplinary perspectives, we emphasize the synergistic role of family functioning and systemic inflammation in shaping maternal mental health outcomes. Recent evidence shows that family-based interventions significantly improve both maternal well-being and infant development. In addition, impaired family dynamics are independently linked to increased antenatal distress, reduced coping, and negative developmental outcomes in children. We advocate for a biopsychosocial approach that combines biomarker monitoring with family counseling as a promising strategy for comprehensive perinatal care. Closing the implementation gap between research and clinical practice is crucial to ensure equitable access to integrative maternal mental health services.