Deoxynivalenol regulates intestinal and stem cell regeneration via the Hippo pathway and clinical intervention strategies

IF 2.4 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2025-08-26 DOI:10.1016/j.toxicon.2025.108553

Peng Liao

引用次数: 0

Abstract

This review article examines the molecular pathways through which the environmental contaminant deoxynivalenol (DON) influences the regeneration and renewal of both intestinal tissues and intestinal stem cells via the Hippo Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signaling cascade, while also exploring possible clinical intervention approaches. To begin, the review outlines the prevalent issue of DON contamination and its adverse effects on gastrointestinal health, underscoring the necessity for a comprehensive understanding of its implications. Subsequently, the discussion focuses on the significance of the Hippo YAP/TAZ pathway in preserving the homeostasis of intestinal stem cells and clarifies the mechanisms by which DON perturbs this essential process. In conclusion, the article consolidates potential therapeutic targets and clinical strategies designed to mitigate the intestinal damage caused by DON, thereby providing fresh perspectives on treatment options for gut injuries.

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脱氧雪腐镰刀菌醇通过Hippo通路和临床干预策略调节肠道和干细胞再生

本文综述了环境污染物脱氧腐血毒素醇（DON）通过Hippo yes相关蛋白(YAP)/带pdz结合基序（TAZ）信号级联的转录共激活因子（transcriptional co-activator with pdz binding motif， TAZ）影响肠道组织和肠道干细胞再生和更新的分子途径，同时探讨了可能的临床干预方法。首先，综述概述了DON污染的普遍问题及其对胃肠道健康的不利影响，强调了全面了解其影响的必要性。随后，讨论重点是Hippo YAP/TAZ通路在维持肠道干细胞稳态中的意义，并阐明DON干扰这一重要过程的机制。总之，本文整合了旨在减轻DON引起的肠道损伤的潜在治疗靶点和临床策略，从而为肠道损伤的治疗选择提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

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