Mushrooms to brushes: Tackling the PEG dilemma in mRNA lipid nanoparticles with complex polymers

IF 17.5 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Matter Pub Date : 2025-09-03 DOI:10.1016/j.matt.2025.102386

Kidus E. Biru , Benjamin M. Fiedler , Pratik Gurnani

引用次数: 0

Abstract

Antibodies against poly(ethylene glycol) (PEG) accelerate lipid nanoparticle clearance and increase reactogenicity. A recent paper explores solutions using branched PEG alternatives that reduce anti-PEG antibody (APA) binding and improve therapeutic outcomes in multi-dose protein replacement and Cas9 gene editing models, opening avenues for the use of LNPs in chronic settings.

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蘑菇到刷子：用复杂聚合物解决mRNA脂质纳米颗粒中的PEG困境

针对聚乙二醇（PEG）的抗体加速脂质纳米颗粒的清除并增加反应原性。最近的一篇论文探讨了使用分支PEG替代品的解决方案，这些替代品可以减少抗PEG抗体（APA）的结合，并改善多剂量蛋白质替代和Cas9基因编辑模型的治疗结果，为在慢性疾病中使用LNPs开辟了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Matter MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

26.30

自引率

2.60%

发文量

367

期刊介绍： Matter, a monthly journal affiliated with Cell, spans the broad field of materials science from nano to macro levels,covering fundamentals to applications. Embracing groundbreaking technologies,it includes full-length research articles,reviews, perspectives,previews, opinions, personnel stories, and general editorial content. Matter aims to be the primary resource for researchers in academia and industry, inspiring the next generation of materials scientists.