Characterizing Hemodynamic Alterations in Glioma: Insights From Resting-State Functional MRI

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2025-09-02 DOI:10.1111/jon.70082

Jun Kanzawa, Shiori Amemiya, Hidemasa Takao, Osamu Abe

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Abstract

Background and Purpose

This study aims to characterize hemodynamic alterations in gliomas by analyzing global signal metrics and amplitude of low-frequency fluctuations (ALFF).

Methods

We analyzed resting-state functional MRI data from an open dataset. A total of 29 glioma patients (17 men; mean age: 44.2 ± 13.9 years; 16 high-grade) were included. Global signal cross-correlation (GSXC), representing the maximum cross-correlation value between each voxel's time series and the average gray matter signal of the contralateral hemisphere, and ALFF were calculated. Regions of interest for tumor were defined and mirrored to the contralateral side for comparison. Linear mixed-effects models were used to examine effects of tumor grade and measurement side on GSXC and ALFF. Post hoc analyses compared tumor versus contralateral regions.

Results

GSXC was significantly reduced in tumor regions compared to the contralateral hemisphere, regardless of tumor grade (low-grade: 0.31 ± 0.21 vs. 0.45 ± 0.16, p = 0.005; high-grade: 0.39 ± 0.17 vs. 0.55 ± 0.13, p < 0.001). ALFF was significantly lower in low-grade tumors compared to the contralateral side (0.65 ± 0.15 vs. 0.77 ± 0.14, p = 0.005), while no significant difference was found in high-grade tumors (0.80 ± 0.18 vs. 0.77 ± 0.10, p = 0.46).

Conclusions

Our findings suggest that GSXC and ALFF provide complementary pathological information on glioma. GSXC indicates impaired cerebrovascular reactivity due to gliovascular uncoupling, whereas ALFF shows an increase in high-grade gliomas likely reflecting greater total vascularity.

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表征胶质瘤的血流动力学改变：来自静息状态功能MRI的见解

背景与目的本研究旨在通过分析神经胶质瘤的整体信号指标和低频波动（ALFF）的幅度来表征血液动力学的改变。方法对开放数据集的静息状态功能MRI数据进行分析。共纳入29例胶质瘤患者（男性17例，平均年龄44.2±13.9岁，高级别16例）。计算各体素时间序列与对侧半球平均灰质信号的最大互相关值Global signal cross-correlation （GSXC）和ALFF。确定肿瘤感兴趣的区域，并镜像到对侧进行比较。采用线性混合效应模型检验肿瘤分级和测量侧对GSXC和ALFF的影响。事后分析比较肿瘤和对侧区域。结果与对侧半球相比，GSXC在肿瘤区域显著减少，与肿瘤分级无关（低分级：0.31±0.21 vs 0.45±0.16,p = 0.005；高分级：0.39±0.17 vs 0.55±0.13,p < 0.001）。低级别肿瘤的ALFF明显低于对侧（0.65±0.15比0.77±0.14,p = 0.005），而高级别肿瘤的ALFF差异无统计学意义（0.80±0.18比0.77±0.10,p = 0.46）。结论GSXC和ALFF为胶质瘤提供了互补的病理信息。GSXC表明由于胶质血管解偶联导致脑血管反应性受损，而ALFF显示高级别胶质瘤的增加可能反映了更大的总血管。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!