Exploring the multifaceted potential of ZrO2 nanoparticles: sustainable synthesis, anticancer properties, and electrochemical insight

IF 2.1 4区 材料科学 Q2 MATERIALS SCIENCE, CERAMICS
N. P. Bhagya, Srilatha Rao, G. K. Prashanth, A. S. Sowmyashree, Smitha Shree S, H. S. Lalithamba, S. R. Yashodha, Manoj Gadewar
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Abstract

This work presents a comprehensive investigation into the sustainable synthesis and extensive characterization of zirconium oxide (ZrO2) nanopowder. The study examines the anticancer properties of the synthesized nanoparticles as well as their electrochemical behavior using potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS). The fascinating attributes of ZrO2 nanoparticles were elucidated through detailed analyses, including powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FESEM), Fourier-transform infrared spectroscopy (FT-IR), and UV–visible spectroscopy (UV–vis). PXRD analysis confirmed a monoclinic crystal structure with crystallite size within the range of 30–40 nm. FESEM reveals irregular shapes and agglomeration of particles, UV–vis showed absorption peak at 347 nm with an energy gap (Eg) of 3.16 eV and FT-IR studies reveals metal–oxygen bonds at 594 cm⁻1. Additionally, electrochemical studies using PDP and EIS investigated the inhibition efficiency of nanoparticles dispersed in an acidic medium (1 M HCl). Anti-oncogenic studies conducted via MTT assay illustrated the efficacy of ZrO2 NPs against the MDA-MB-231 cell line with an IC50 value of 22.56 µg/mL. Our findings underscore the versatile potential applications of ZrO2 nanoparticles and provide significant new insights into their optical, structural, electrochemical, and anticancer properties.

探索ZrO2纳米颗粒的多方面潜力:可持续合成,抗癌特性和电化学见解
本文对氧化锆(ZrO2)纳米粉体的可持续合成和广泛表征进行了全面研究。本研究利用动电位极化(PDP)和电化学阻抗谱(EIS)研究了合成的纳米颗粒的抗癌特性及其电化学行为。通过粉末x射线衍射(PXRD)、场发射扫描电子显微镜(FESEM)、傅里叶变换红外光谱(FT-IR)和紫外可见光谱(UV-vis)等详细分析,阐明了ZrO2纳米颗粒的迷人属性。PXRD分析证实为单斜晶结构,晶粒尺寸在30-40 nm范围内。FESEM显示出不规则的形状和颗粒聚集,UV-vis显示吸收峰在347 nm处,能隙(Eg)为3.16 eV, FT-IR研究显示金属-氧键在594 cm⁻1处。此外,利用PDP和EIS的电化学研究考察了分散在酸性介质(1 M HCl)中的纳米颗粒的抑制效率。MTT实验显示ZrO2 NPs对MDA-MB-231细胞株的抑癌作用,IC50值为22.56µg/mL。我们的发现强调了ZrO2纳米颗粒的多种潜在应用,并为其光学、结构、电化学和抗癌特性提供了重要的新见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of the Australian Ceramic Society
Journal of the Australian Ceramic Society Materials Science-Materials Chemistry
CiteScore
3.70
自引率
5.30%
发文量
123
期刊介绍: Publishes high quality research and technical papers in all areas of ceramic and related materials Spans the broad and growing fields of ceramic technology, material science and bioceramics Chronicles new advances in ceramic materials, manufacturing processes and applications Journal of the Australian Ceramic Society since 1965 Professional language editing service is available through our affiliates Nature Research Editing Service and American Journal Experts at the author''s cost and does not guarantee that the manuscript will be reviewed or accepted
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