Anti-cancer effect of Thymus vulgaris based synthesized gold nanoparticles in giant macroporous silica: impact on MCF-7 breast cancer cells

IF 2.1 4区 材料科学 Q2 MATERIALS SCIENCE, CERAMICS
Behlul Koc-Bilican, Samiha Benarous, Fatih Dogan Koca, Demet Cansaran-Duman, Martin Vinther Sørensen, Ismail Bilican, Murat Kaya
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引用次数: 0

Abstract

Conventional cancer therapies, while effective, are frequently associated with significant adverse effects owing to their lack of selectivity, impacting both malignant and healthy cells. To address these challenges, gold nanoparticles (AuNPs) have emerged as a promising platform for targeted drug delivery. Giant macroporous silica (GMS) is a recently developed material, with its drug delivery potential explored in only a single study to date. In this study, gold nanoparticles (AuNPs) synthesized using Thymus vulgaris (garden thyme) extract were incorporated into GMS, forming GMS-AuNPs. Additionally, AuNPs coated with chitosan (AuNPs@CS) were similarly loaded into GMS, resulting in GMS-AuNPs@CS composites. The synthesized materials were characterized through light microscopy, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. The anti-cancer effects of GMS-AuNPs and GMS-AuNPs@CS were assessed against breast cancer cells using real-time cell analysis. Notably, no cytotoxic effects were observed on MCF-12 A normal breast epithelial cells at any of the tested concentrations. GMS-AuNPs demonstrated a dose- and time-dependent cytotoxic effect on breast cancer cells. These findings suggest that GMS-AuNPs hold promise as a potential therapeutic strategy for breast cancer treatment.

巨孔二氧化硅中胸腺合成金纳米颗粒的抗癌作用:对MCF-7乳腺癌细胞的影响
传统的癌症治疗方法虽然有效,但由于缺乏选择性,往往会对恶性细胞和健康细胞造成严重的不良影响。为了解决这些挑战,金纳米颗粒(AuNPs)已经成为一种有前途的靶向药物递送平台。巨孔二氧化硅(GMS)是一种新开发的材料,迄今为止仅在一项研究中探索了其给药潜力。本研究将百里香提取物合成的金纳米颗粒(AuNPs)加入到GMS中,形成GMS-AuNPs。此外,用壳聚糖(AuNPs@CS)包裹的AuNPs同样被装入GMS中,得到GMS-AuNPs@CS复合材料。通过光镜、扫描电镜和能量色散x射线能谱对合成材料进行了表征。通过实时细胞分析评估GMS-AuNPs和GMS-AuNPs@CS对乳腺癌细胞的抗癌作用。值得注意的是,在任何测试浓度下,均未观察到对mcf - 12a正常乳腺上皮细胞的细胞毒性作用。GMS-AuNPs对乳腺癌细胞具有剂量和时间依赖性的细胞毒性作用。这些发现表明,GMS-AuNPs有望成为乳腺癌治疗的潜在治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of the Australian Ceramic Society
Journal of the Australian Ceramic Society Materials Science-Materials Chemistry
CiteScore
3.70
自引率
5.30%
发文量
123
期刊介绍: Publishes high quality research and technical papers in all areas of ceramic and related materials Spans the broad and growing fields of ceramic technology, material science and bioceramics Chronicles new advances in ceramic materials, manufacturing processes and applications Journal of the Australian Ceramic Society since 1965 Professional language editing service is available through our affiliates Nature Research Editing Service and American Journal Experts at the author''s cost and does not guarantee that the manuscript will be reviewed or accepted
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