Pathogenicity of the First Buffalo-origin Senecavirus A in Conventional Piglets and Buffaloes

IF 3 2区农林科学 Q2 INFECTIOUS DISEASES

Transboundary and Emerging Diseases Pub Date : 2025-09-02 DOI:10.1155/tbed/6222217

Xia Zhou, Qi Zhai, Jiawei Niu, Gen Li, Tianbao Chen, Yan Li, Huahua Kang, Chunling Li, Hongchao Gou, Pinpin Chu, Kunli Zhang, Zhiyong Jiang, Zhibiao Bian, Ming Liao, Shao-Lun Zhai

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Abstract

As the only member of the genus Senecavirus within the family Picornaviridae, Senecavirus A (SVA) has posed an enormous challenge for the pig industry worldwide. In our previous study, a SVA strain was isolated from a buffalo with mouth ulcers. To systematically assess its pathogenicity, this study compared the outcome of piglets and buffaloes artificially infected by the different viral dose of the buffalo-origin SVA strain (SVA/GD/China/2018). These results indicated that vesicular diseases can occur in infected piglets and buffaloes. Severe clinical symptoms were observed in the piglets and buffaloes with the inoculation of 10^5.0 50% tissue culture infective dose (TCID₅₀/mL). The SVA antigen expression was also detected in the lung tissue, chin blister lesion tissue, nasolabial tissue of the piglets, and the upper lip blister tissue of the buffaloes. This study demonstrated that the buffalo-origin SVA strain was pathogenic to piglets and buffaloes, revealing the possibility of cross-species transmission of SVA between pigs and buffaloes. In the future, it is necessary to strengthen the surveillance of SVA in cattle herds.

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第一水牛源塞内卡病毒A在普通仔猪和水牛中的致病性

作为小核糖核酸病毒科塞内卡病毒属的唯一成员，塞内卡病毒A （SVA）对全世界的养猪业构成了巨大的挑战。在我们之前的研究中，从患有口腔溃疡的水牛中分离出一种SVA菌株。为了系统评估其致病性，本研究比较了不同病毒剂量的水牛源SVA菌株（SVA/GD/China/2018）人工感染仔猪和水牛的结果。这些结果表明，受感染的仔猪和水牛可发生水疱病。接种105.0 ~ 50%组织培养感染剂量（TCID50/mL）的仔猪和水牛出现严重的临床症状。在仔猪肺组织、下巴水疱病变组织、鼻唇组织和水牛上唇水疱组织中均检测到SVA抗原的表达。本研究表明，来自水牛的SVA菌株对仔猪和水牛具有致病性，揭示了SVA在猪和水牛之间跨物种传播的可能性。今后有必要加强对牛群SVA的监测。

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来源期刊

Transboundary and Emerging Diseases 农林科学-传染病学

CiteScore

8.90

自引率

9.30%

发文量

350

审稿时长

1 months

期刊介绍： Transboundary and Emerging Diseases brings together in one place the latest research on infectious diseases considered to hold the greatest economic threat to animals and humans worldwide. The journal provides a venue for global research on their diagnosis, prevention and management, and for papers on public health, pathogenesis, epidemiology, statistical modeling, diagnostics, biosecurity issues, genomics, vaccine development and rapid communication of new outbreaks. Papers should include timely research approaches using state-of-the-art technologies. The editors encourage papers adopting a science-based approach on socio-economic and environmental factors influencing the management of the bio-security threat posed by these diseases, including risk analysis and disease spread modeling. Preference will be given to communications focusing on novel science-based approaches to controlling transboundary and emerging diseases. The following topics are generally considered out-of-scope, but decisions are made on a case-by-case basis (for example, studies on cryptic wildlife populations, and those on potential species extinctions): Pathogen discovery: a common pathogen newly recognised in a specific country, or a new pathogen or genetic sequence for which there is little context about — or insights regarding — its emergence or spread. Prevalence estimation surveys and risk factor studies based on survey (rather than longitudinal) methodology, except when such studies are unique. Surveys of knowledge, attitudes and practices are within scope. Diagnostic test development if not accompanied by robust sensitivity and specificity estimation from field studies. Studies focused only on laboratory methods in which relevance to disease emergence and spread is not obvious or can not be inferred (“pure research” type studies). Narrative literature reviews which do not generate new knowledge. Systematic and scoping reviews, and meta-analyses are within scope.