Synergistic Ferroptosis–Immunotherapy Nanoplatforms: Multidimensional Engineering for Tumor Microenvironment Remodeling and Therapeutic Optimization

IF 36.3 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2025-09-02 DOI:10.1007/s40820-025-01862-6

Xiao Wei, Yanqiu Jiang, Feiyang Chenwu, Zhi Li, Jie Wan, Zhengxi Li, Lele Zhang, Jing Wang, Mingzhu Song

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引用次数: 0

Abstract

Highlights

First systematic integration: This work presents the first comprehensive outline of the synergistic potential of nanoparticle-enabled ferroptosis–immunotherapy strategies against malignancies, moving beyond studies solely focusing on ferroptosis induction or standalone nanotherapeutics in cancer.
Multidimensional nanoplatform design: Establishes advanced design principles for functionalized nanoplatforms, including rational material selection, structural configuration, physicochemical modulation, multifunctional integration, and AI-enabled design, to overcome tumor microenvironment barriers and optimize ferroptosis–immunotherapy efficacy.
Translational focus & AI integration: Provides a critical analysis of translational hurdles for ferroptosis–immunotherapy nanoplatforms across preclinical and clinical development, proposing actionable solutions while pioneering the integration of artificial intelligence into future nanoplatform design and onco-immunotherapy direction.

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协同凋亡-免疫治疗纳米平台：肿瘤微环境重塑和治疗优化的多维工程

第一次系统整合：这项工作首次全面概述了纳米粒子支持的恶性肿瘤铁凋亡免疫治疗策略的协同潜力，超越了仅仅关注铁凋亡诱导或癌症单独纳米治疗的研究。多维纳米平台设计：建立先进的功能化纳米平台设计原则，包括合理的材料选择、结构配置、理化调节、多功能集成和人工智能设计，以克服肿瘤微环境障碍，优化死铁免疫治疗效果。转化焦点& AI整合：对临床前和临床开发中凋亡铁免疫治疗纳米平台的转化障碍进行了批判性分析，提出了可行的解决方案，同时开拓了将人工智能整合到未来纳米平台设计和肿瘤免疫治疗方向的研究。

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来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.