Magnetically enhanced ZnFe2O4 nanocomposite: a promising antibacterial, and antioxidant strategies

IF 3.2 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

Journal of Sol-Gel Science and Technology Pub Date : 2025-07-18 DOI:10.1007/s10971-025-06870-x

Mahdi A. Mohammed, Waleed K. Abdulkadhim, Kareem. H. Jawad, Salim Albukhaty, Majid S. Jabir, Suresh Ghotekar, Ayman A. Swelum

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Abstract

The present study aimed to synthesize zinc ferrite nanoparticles (ZnFe₂O₄ NPs) using the sol-gel method and evaluate their antibacterial properties against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), along with an assessment of their antioxidant activity. Characterization, including X-ray diffraction (XRD) analysis, confirmed that the nanoparticles exhibited a face-centered cubic (FCC) crystalline structure. Transmission electron microscopy (TEM) revealed that the nanoparticles were spherical in shape, with an estimated size ranging from approximately (~30–60 nm). The magnetic properties were investigated using a vibrating sample magnetometer (VSM), while Fourier-transform infrared spectroscopy (FTIR) identified the functional groups present. Notably, this study presents a novel approach by demonstrating, for the first time, the enhanced antibacterial efficacy of ZnFe₂O₄ nanoparticles under an alternating magnetic field (AMF), highlighting their unique DNA-mediated mechanism of action. Furthermore, the ZnFe₂O₄ NPs exhibited sustained antioxidant activity as measured by the DPPH assay. These combined antioxidant and AMF-enhanced antibacterial properties suggest promising pharmacological and biomedical applications for ZnFe₂O₄ NPs, particularly in the development of magnetically responsive therapeutic agents. Notably, this study presents a novel approach by demonstrating, for the first time, the enhanced antibacterial efficacy of ZnFe₂O₄ nanoparticles under an alternating magnetic field (AMF), highlighting their unique DNA-mediated mechanism of action. Furthermore, the ZnFe₂O₄ NPs exhibited sustained antioxidant activity as measured by the DPPH assay. These combined antioxidant and AMF-enhanced antibacterial properties suggest promising pharmacological and biomedical applications for ZnFe₂O₄ NPs, particularly in the development of magnetically responsive therapeutic agents.

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磁增强ZnFe2O4纳米复合材料：一种有前途的抗菌和抗氧化策略

本研究旨在采用溶胶-凝胶法合成铁酸锌纳米颗粒（ZnFe2O4 NPs），并评价其对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）的抗菌性能和抗氧化活性。表征，包括x射线衍射（XRD）分析，证实了纳米颗粒具有面心立方（FCC）晶体结构。透射电子显微镜（TEM）显示，纳米颗粒呈球形，估计尺寸约为（~ 30-60 nm）。用振动样品磁强计（VSM）研究了其磁性能，并用傅里叶变换红外光谱（FTIR）鉴定了其官能团。值得注意的是，本研究提出了一种新颖的方法，首次证明了ZnFe2O4纳米颗粒在交变磁场（AMF）下的增强抗菌效果，突出了其独特的dna介导的作用机制。此外，通过DPPH测定，ZnFe2O4 NPs表现出持续的抗氧化活性。这些抗氧化和amf增强的抗菌特性表明，ZnFe2O4 NPs具有良好的药理和生物医学应用前景，特别是在开发磁响应治疗剂方面。值得注意的是，本研究提出了一种新颖的方法，首次证明了ZnFe2O4纳米颗粒在交变磁场（AMF）下的增强抗菌效果，突出了其独特的dna介导的作用机制。此外，通过DPPH测定，ZnFe2O4 NPs表现出持续的抗氧化活性。这些抗氧化和amf增强的抗菌特性表明，ZnFe2O4 NPs具有良好的药理和生物医学应用前景，特别是在开发磁响应治疗剂方面。图形抽象

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来源期刊

Journal of Sol-Gel Science and Technology 工程技术-材料科学：硅酸盐

CiteScore

4.70

自引率

4.00%

发文量

280

审稿时长

2.1 months

期刊介绍： The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.