Younes Mousavi majd, Amir Arasteh, Ahmad Molaei Rad, Mehdi Ebrahimi
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引用次数: 0
Abstract
Because of their unique physicochemical properties and biological activities, nanocomposites have developed as promising therapeutic active ingredients. This study aimed to examine the synthesis, characterization, and biological effects of green-synthesized silver magnetite nanocomposites using P. harmala aqueous extract (Harmala Ag-Fe3O4 NCs), with a particular focus on their antioxidant, anticancer, and anti-Alzheimer’s characteristics. Harmala Ag-Fe3O4 NCs were synthesized by a green method and characterized using UV-Vis, FTIR, XRD, DLS, and Zeta potential techniques. The magnetic properties were analyzed using VSM (vibrating sample magnetometry). The surface morphology and the elemental composition were examined using FESEM (field emission scanning electron microscopy) and EDAX (energy-dispersive X-ray analysis). The antioxidant activity was evaluated using DPPH, and anticancer effects were evaluated by MTT assay on HT-29 colorectal cancer cells. The anti-amyloidogenic potential was examined by spectrofluorimetry and confirmed by TEM images. UV-Vis, FTIR, and XRD methods confirmed the formation of silver magnetite nanocomposites. The FESEM images showed a nanogranular distribution, and VSM analysis indicated that the sample had low hysteresis, requiring less magnetic field for demagnetization. Harmala Ag-Fe3O4 NCs showed strong inhibitory effects on amyloids, with the highest antioxidant activity (78%) observed at 10 mg/ml, and maximum anticancer effects observed at 500 µg/ml. This study shows that Harmala Ag-Fe3O4 NCs have significant antioxidant, anti-Alzheimer’s, and anticancer properties, indicating their potential therapeutic applications in cancer treatment and neurodegenerative diseases.
期刊介绍：
The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.
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