Meredith Yellen , Rangesh Modi , Rebecca Yao , Tanner Storozuk , Kevin Tanager , Kg Reddy
{"title":"Drug-Induced Dysphagia and Diarrhea: A Case of Colchicine Toxicity","authors":"Meredith Yellen , Rangesh Modi , Rebecca Yao , Tanner Storozuk , Kevin Tanager , Kg Reddy","doi":"10.1016/j.gastha.2025.100726","DOIUrl":null,"url":null,"abstract":"<div><div>We report a 70-year-old woman with 1 year of progressive diarrhea, dysphagia, and 100-pound weight loss, resulting in severe protein–calorie malnutrition. Endoscopy revealed mid-esophageal webs, erosions, erythema, gastric antrum and duodenum congestion, and mucosal granularity in the sigmoid colon. Biopsies from the esophagus, duodenum, and colon showed ring mitoses, prominent dyskeratosis/apoptosis, epithelial atypia, and regenerative changes consistent with colchicine toxicity. Her symptoms resolved within 3 days of discontinuing colchicine.</div></div>","PeriodicalId":73130,"journal":{"name":"Gastro hep advances","volume":"4 10","pages":"Article 100726"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastro hep advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S277257232500113X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
We report a 70-year-old woman with 1 year of progressive diarrhea, dysphagia, and 100-pound weight loss, resulting in severe protein–calorie malnutrition. Endoscopy revealed mid-esophageal webs, erosions, erythema, gastric antrum and duodenum congestion, and mucosal granularity in the sigmoid colon. Biopsies from the esophagus, duodenum, and colon showed ring mitoses, prominent dyskeratosis/apoptosis, epithelial atypia, and regenerative changes consistent with colchicine toxicity. Her symptoms resolved within 3 days of discontinuing colchicine.
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