Phosphine-mediated deoxygenative synthesis of amides from carboxylic acids and N-chloro compounds

Abstract

A strategy for amide synthesis through the deoxygenation of carboxylic acids with N-chloro compounds using a phosphine-mediated P(V) platform is reported. This method enables the efficient conversion of various carboxylic acids, including primary, secondary, and bioactive molecules, as well as amino acids, into amides under mild conditions. The scalability of the reaction highlights its practical applicability for large-scale amide production. This approach offers a new perspective on activation reagents, focusing on aniline activation rather than conventional carboxylic acid activation.