Effects of Asparagus officinalis for burning mouth syndrome: A systematic review of randomized controlled trials

IF 3 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Integrative Medicine Research Pub Date : 2025-08-10 DOI:10.1016/j.imr.2025.101223

Chen Shen , Xue-Feng Wang , Xiao-Ti Wu , Xin-Xin Liu , Nicola Robinson , Jian-Ping Liu

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引用次数: 0

Abstract

Background

Burning mouth syndrome (BMS) lacks optimal treatments. This systematic review assessed Asparagus officinalis, a natural product with anti-inflammatory/antioxidant properties, for managing this chronic pain disorder.

Methods

PubMed, the Cochrane Library, EMBASE, Web of Science, Scopus, and four Chinese databases were searched until February, 2025 for randomized controlled trials (RCTs) involving adults with BMS. Asparagus officinalis products alone or in combination with conventional medications were included. Outcomes included pain, symptoms, psychological outcomes and salivary function. The GRADE approach was used to assess evidence certainty.

Results

Six RCTs with 336 participants were included. Compared to vitamin B complex alone, Asparagus officinalis capsules alone significantly improved the pain-intensity-based effective rate (RR 6.00, 95 % CI [1.61, 22.34]). Compared to conventional medicines, Asparagus officinalis capsules with conventional medicines significantly increased subjective pain scores (MD 1.51, 95 % CI [1.19, 1.83]), symptom-based effective rate (RR 1.27, 95 % CI [1.14, 1.42]), daily water intake score (MD 1.32, 95 % CI [1.00, 1.64]), sleep duration score (MD 1.88, 95 % CI [1.61, 2.15]), and decreased anxiety and depression scores, while Asparagus officinalis oral liquid combined with mecobalamin significantly reduced 10-point VAS (MD -1.40, 95 % CI [-2.19, -0.61]) and increased the unstimulated salivary flow rate (USFR).The certainty of evidence was all graded as low.

Conclusions

Asparagus officinalis products may improve pain intensity, symptoms, psychological outcomes, and salivary function in patients with BMS. However, the low certainty of evidence due to study limitations and small sample sizes suggests the need for well-designed, large-scale real-world studies to confirm these findings and establish their clinical applicability.

Protocol registration

PROSPERO (CRD420250651920).

查看原文本刊更多论文

芦笋治疗灼口综合征的疗效：随机对照试验的系统综述

灼口综合征（BMS）缺乏最佳治疗方法。本系统综述评估了芦笋，一种具有抗炎/抗氧化特性的天然产品，用于治疗这种慢性疼痛疾病。方法检索spubmed、Cochrane Library、EMBASE、Web of Science、Scopus和4个中文数据库，截至2025年2月，检索涉及成年BMS患者的随机对照试验（RCTs）。芦笋产品单独使用或与常规药物联合使用。结果包括疼痛、症状、心理结果和唾液功能。GRADE方法用于评估证据的确定性。结果共纳入6项随机对照试验，共336名受试者。与单独使用维生素B复合物相比，芦笋胶囊可显著提高基于疼痛强度的有效率（RR 6.00, 95% CI[1.61, 22.34]）。与常规药物相比，芦竹胶囊联合常规药物显著提高主观疼痛评分（MD 1.51, 95% CI[1.19, 1.83]）、症状有效率（RR 1.27, 95% CI[1.14, 1.42]）、每日饮水量评分（MD 1.32, 95% CI[1.00, 1.64]）、睡眠时间评分（MD 1.88, 95% CI[1.61, 2.15]），降低焦虑和抑郁评分。芦笋口服液联合甲钴胺可显著降低10点VAS (MD -1.40, 95% CI[-2.19, -0.61])，提高非刺激唾液流率（USFR）。证据的确定性都被评为低。结论芦笋制品可改善BMS患者的疼痛强度、症状、心理结局和唾液功能。然而，由于研究的局限性和小样本量，证据的低确定性表明需要精心设计的大规模现实世界研究来证实这些发现并建立其临床适用性。协议注册prospero （CRD420250651920）。

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来源期刊

Integrative Medicine Research Medicine-Complementary and Alternative Medicine

CiteScore

6.50

自引率

2.90%

发文量

审稿时长

12 weeks

期刊介绍： Integrative Medicine Research (IMR) is a quarterly, peer-reviewed journal focused on scientific research for integrative medicine including traditional medicine (emphasis on acupuncture and herbal medicine), complementary and alternative medicine, and systems medicine. The journal includes papers on basic research, clinical research, methodology, theory, computational analysis and modelling, topical reviews, medical history, education and policy based on physiology, pathology, diagnosis and the systems approach in the field of integrative medicine.