Enantioselective Ni-catalyzed reductive cross-coupling of propargyl halides with vinyl halides to skipped enynes

Abstract

Skipped enynes represent valuable structural motifs in synthetic chemistry due to their unique reactivity and prevalence in complex molecules. Herein, we describe a streamlined approach for the enantioselective synthesis of chiral skipped enynes via nickel-catalyzed asymmetric reductive cross-coupling between propargyl halides and vinyl halides. This transformation offers several notable advantages, including the use of readily available starting materials, mild reaction conditions, broad functional group tolerance, and potential for diverse downstream functionalizations.