Synthetic ion channel modulator reverses sodium channel dysfunction linked to cardiac arrhythmias

IF 44.2 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Nature Reviews Cardiology Pub Date : 2025-09-01 DOI:10.1038/s41569-025-01207-1

Karina Huynh

引用次数: 0

Abstract

Investigators of a new study published in Cell have engineered a new peptide modulator that binds to sodium channels to inhibit the late sodium current, which was shown to reverse the effects of sodium channel dysfunction associated with cardiac arrhythmias and epilepsy.

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合成离子通道调节剂逆转与心律失常相关的钠通道功能障碍

发表在《细胞》杂志上的一项新研究的研究人员设计了一种新的肽调节剂，它与钠通道结合，抑制晚期钠电流，这被证明可以逆转与心律失常和癫痫相关的钠通道功能障碍的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cardiology 医学-心血管系统

CiteScore

53.10

自引率

0.60%

发文量

143

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cardiology aims to be the go-to source for reviews and commentaries in the scientific and clinical communities it serves. Focused on providing authoritative and accessible articles enriched with clear figures and tables, the journal strives to offer unparalleled service to authors, referees, and readers, maximizing the usefulness and impact of each publication. It covers a broad range of content types, including Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives, catering to practising cardiologists and cardiovascular research scientists. Authored by renowned clinicians, academics, and researchers, the content targets readers in the biological and medical sciences, ensuring accessibility across various disciplines. In-depth Reviews offer up-to-date information, while Consensus Statements provide evidence-based recommendations. Perspectives and News & Views present topical discussions and opinions, and the Research Highlights section filters primary research from cardiovascular and general medical journals. As part of the Nature Reviews portfolio, Nature Reviews Cardiology maintains high standards and a wide reach.