Roles of long non-coding RNAs in oesophageal cancer pathogenesis

IF 2.2 4区 医学 Q3 PATHOLOGY
Nan Jiang, Beibei Hu, Xin Shu, Gen Li, Jinguang Wang, Changsheng Lv
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引用次数: 0

Abstract

With high morbidity and mortality internationally, oesophageal cancer is one of the most common diseases of the digestive system. The most frequent approaches to the treatment of oesophageal cancer are a combination of chemotherapy and radiation therapy. Inevitably, some individuals with oesophageal cancer fail to respond favourably to these treatments because of therapeutic resistance, with eventual unfavourable outcomes. Thus, it would be helpful if patients with oesophageal cancer learned more about the pathophysiology of the disease. Discovering early-detection biomarkers could help to identify prognostic markers. Long non-coding RNAs (lncRNAs) are endogenous RNAs with more than 200 nucleotides that do not code for proteins, and these have been recognised increasingly as being important in cancer. A few of the lncRNAs have been shown to be associated with oesophageal cancer. When target gene expression is inhibited or promoted, lncRNAs can play a role in cell growth, apoptosis and metastasis, among other functions in biology, and are aberrantly produced in oesophageal cancer. Using epithelial–mesenchymal transition (EMT), which is implicated in the occurrence, development and diagnosis of oesophageal cancer, lncRNAs may regulate the natural history of the disease. Thus in this article we have reviewed the biological and molecular mechanisms of lncRNAs, including their role as suppressors of tumours as well as in malignancy, in relationship to oesophageal cancer. Furthermore, we have extrapolated from this analysis some potential A lncRNA candidates for oesophageal cancer detection, prediction and treatment. Lastly, we debate both the potential and the difficulties about how lncRNAs may influence oesophageal cancer.

Abstract Image

长链非编码rna在食管癌发病机制中的作用
食管癌是世界上最常见的消化系统疾病之一,具有很高的发病率和死亡率。食管癌最常用的治疗方法是化疗和放疗相结合。不可避免的是,一些食管癌患者由于治疗耐药性而无法对这些治疗产生良好的反应,最终导致不利的结果。因此,如果食管癌患者对疾病的病理生理有更多的了解,将是有帮助的。发现早期检测的生物标志物可以帮助确定预后标志物。长链非编码rna (lncRNAs)是内源性rna,有超过200个核苷酸不编码蛋白质,它们在癌症中越来越被认为是重要的。一些lncrna已被证明与食管癌有关。当靶基因表达受到抑制或促进时,lncRNAs可在细胞生长、凋亡和转移等生物学功能中发挥作用,并在食管癌中异常产生。通过参与食管癌发生、发展和诊断的上皮-间质转化(EMT), lncRNAs可能调控该疾病的自然史。因此,在本文中,我们综述了lncrna的生物学和分子机制,包括它们作为肿瘤和恶性肿瘤抑制因子的作用,以及与食管癌的关系。此外,我们还从这一分析中推断出一些潜在的用于食管癌检测、预测和治疗的A lncRNA候选者。最后,我们讨论了lncrna如何影响食管癌的潜力和困难。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.50
自引率
3.30%
发文量
35
审稿时长
>12 weeks
期刊介绍: Experimental Pathology encompasses the use of multidisciplinary scientific techniques to investigate the pathogenesis and progression of pathologic processes. The International Journal of Experimental Pathology - IJEP - publishes papers which afford new and imaginative insights into the basic mechanisms underlying human disease, including in vitro work, animal models, and clinical research. Aiming to report on work that addresses the common theme of mechanism at a cellular and molecular level, IJEP publishes both original experimental investigations and review articles. Recent themes for review series have covered topics as diverse as "Viruses and Cancer", "Granulomatous Diseases", "Stem cells" and "Cardiovascular Pathology".
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