Duplex-Channel Plasmonic Biosensor for Simultaneous Detection of Multiple Cancer Cells

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-07-10 DOI:10.1007/s11468-025-03172-4

Sunita Debbarma, Puspa Devi Pukhrambam

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引用次数: 0

Abstract

A novel duplex-channel biosensor designed for simultaneous detection of cervical cancer and adrenal gland cancer is proposed here. The surface plasmon resonance (SPR)-based photonic crystal fiber (PCF) uses a thin film of Ta₂O₅ and gold for cancer cell detection. The finite element method (FEM)-based confinement loss (C_L) analysis is used for geometrical optimization. The right and left slots are denoted by Channel 1 (Ch1), and Channel 2 (Ch2) is the label for vertically positioned top and bottom slots, respectively. Two channels are separated by a thick barrier of silica layer to prevent direct contacts between two neighboring channels such that the analytes in each channel will not mix up. Simulation results show that Channel 1 with adrenal cancer cells supports y-polarized electric field modes, whereas Channel 2 with cervical cancer cells supports x-polarized modes. For cervical and adrenal cancer cells, the sensor’s amplitude sensitivities are 1168.83 RIU⁻¹ and 394.29 RIU⁻¹, respectively, while its wavelength sensitivities are 8333.33 nm/RIU and 12,142.86 nm/RIU. The suggested sensor is a circular-shaped, dual-channel PCF sensor capable of detecting two separate analytes at the same time. The sensor uses an external sensing technique, which is affordable; liquid sample infiltration will be simpler, and it will make the sensing mechanism more convenient. With the ability to identify multiple cancer cells at once, the suggested sensor is a good fit for the biosensing applications in healthcare.

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用于同时检测多种癌细胞的双通道等离子体生物传感器

本文提出了一种用于宫颈癌和肾上腺癌同时检测的新型双通道生物传感器。基于表面等离子体共振（SPR）的光子晶体光纤（PCF）使用Ta₂O₅和金薄膜进行癌细胞检测。采用基于有限元法的约束损耗分析进行几何优化。左右槽位分别用通道1 （Ch1）表示，通道2 （Ch2）分别为上下槽位垂直位置的标签。两个通道由厚厚的二氧化硅层屏障隔开，以防止两个相邻通道之间的直接接触，从而使每个通道中的分析物不会混合。模拟结果表明，含有肾上腺癌细胞的通道1支持y极化电场模式，而含有宫颈癌细胞的通道2支持x极化电场模式。对于宫颈癌和肾上腺癌细胞，该传感器的振幅灵敏度分别为1168.83 RIU−1和394.29 RIU−1，波长灵敏度分别为8333.33 nm/RIU和12142.86 nm/RIU。建议的传感器是一个圆形，双通道PCF传感器，能够同时检测两种分离的分析物。该传感器采用外部传感技术，价格实惠；液体样品的渗透将更简单，使传感机构更方便。该传感器具有一次识别多个癌细胞的能力，非常适合医疗保健领域的生物传感应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.