Detection of Urine Glucose Concentration Using Zirconium Nitride Surface Plasmon Resonance Sensor

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-03-06 DOI:10.1007/s11468-025-02853-4

Rajeev Kumar, Yash Sharma, Sudhakar T., Subhashree Ray, Rekha M. M., Bhavik Jain, Amrindra Pal

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引用次数: 0

Abstract

A zirconium nitride (ZrN)-coated surface plasmon resonance (SPR) biosensor that targets particular biological components has been designed and simulated in this study. We illustrated the detection of glucose concentration in urine samples using numerical simulation based on the finite element method (FEM). The maximum angular sensitivity of the sensor was 315.74°/RIU at 0–15 mg/dl (normal range) and 10 g/dl of glucose concentration using refractive indices with a thickness of 48 nm and 2 nm of Ag and ZrN layer. Moreover, for the various concentrations like 0.625, 1.25, 2.5, 5, and 10 g/dl, the sensitivity of 245.22°/RIU, 247.8°/RIU, 250.57°/RIU, 259.93°/RIU, and 283.42°/RIU are attained at minimum reflectivity (R_min) respectively. The corresponding penetration depth (PD) values are observed at 214.8, 216.4, 220.6, 222.3, 230.5, and 233.3 nm, respectively. Therefore, the improved performance of the current SPR biosensor opens a new field in medical science and is suitable for urine glucose detection.

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氮化锆表面等离子体共振传感器检测尿糖浓度

本研究设计并模拟了一种针对特定生物成分的氮化锆（ZrN）涂层表面等离子体共振（SPR）生物传感器。我们用基于有限元法（FEM）的数值模拟说明了尿液样本中葡萄糖浓度的检测。该传感器在0-15 mg/dl（正常范围）和10 g/dl葡萄糖浓度下的最大角灵敏度为315.74°/RIU，使用厚度分别为48 nm和2 nm的Ag和ZrN层的折射率。此外，对于0.625、1.25、2.5、5和10 g/dl等不同浓度，最小反射率（Rmin）下的灵敏度分别为245.22°/RIU、247.8°/RIU、250.57°/RIU、259.93°/RIU和283.42°/RIU。分别在214.8、216.4、220.6、222.3、230.5和233.3 nm处观察到相应的穿透深度（PD）值。因此，当前SPR生物传感器性能的提高，在医学上开辟了一个新的领域，适用于尿糖检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.