Design and Optimization of a Novel SPR Sensor for Detecting Cancerous Cells: A Simulation-Based Study

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-06-02 DOI:10.1007/s11468-025-03057-6

Bhishma Karki, Amrindra Pal, Arun Uniyal, Manashree, Pushkar Jassal, Aashna Sinha

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引用次数: 0

Abstract

This numerical work uses a surface plasmon resonance (SPR)-based Kretschmann sensor structure to examine early cancer detection. The proposed optical sensor is intended to identify different types of cancer-infected cells in the human body with refractive indices (RIs) between 1.38 and 1.401. It performs well across various RI changes, including biological solutions. The sensor is designed and analyzed using a MATLAB simulation platform based on the transfer matrix method (TMM). Characteristic parameters like sensitivity (S), full width at half maximum (FWHM), detection accuracy (DA), and figure of merit (FoM) are used to assess the suggested SPR sensor’s performance. With a maximum FoM of 166.07 RIU⁻¹ and DA of 0.465°⁻¹, the numerical findings demonstrate that the developed sensor can detect skin, cervical, blood, adrenal gland, and type I and type II breast cancer with a sensitivity of 200, 245.83, 257.14, 303.57, 353.57, and 357.14°/RIU, respectively. Based on the obtained results, we think that the proposed SPR sensor may find use in medical science for early cancer detection, which would open up new possibilities in the biosensing sector.

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一种用于检测癌细胞的新型SPR传感器的设计与优化：基于模拟的研究

这项数值工作使用基于表面等离子体共振（SPR）的克雷茨曼传感器结构来检测早期癌症检测。所提出的光学传感器旨在识别人体中折射率（RIs）在1.38至1.401之间的不同类型的癌症感染细胞。它在各种RI变化（包括生物解决方案）中表现良好。基于传递矩阵法（TMM），利用MATLAB仿真平台对传感器进行了设计和分析。特性参数，如灵敏度(S)，半最大全宽度（FWHM），检测精度（DA），和优点数（FoM）被用来评估建议的SPR传感器的性能。该传感器检测皮肤、宫颈、血液、肾上腺以及I型和II型乳腺癌的灵敏度分别为200、245.83、257.14、303.57、353.57和357.14°/RIU，最大FoM为166.07 RIU−1，DA为0.465°−1。基于所获得的结果，我们认为所提出的SPR传感器可能会在医学科学中用于早期癌症检测，这将为生物传感领域开辟新的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.