Near Infrared Sensing of Liver Cancer Using Fiber Optic SPR Biosensor in Performance Enhancement Using Optimum Radiation Damping

IF 4.3 4区物理与天体物理 Q2 CHEMISTRY, PHYSICAL

Plasmonics Pub Date : 2025-07-01 DOI:10.1007/s11468-025-03162-6

Adarsh Chandra Mishra, D. K. Dwivedi, Anuj K. Sharma, Pooja Lohia

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引用次数: 0

Abstract

The study presents a theoretical and computational study of a ZBLAN fiber-based SPR sensor in the NIR region of wavelength. Malignant liver tissues are considered as analytes, and the analysis is carried out under the phenomenon of optimum radiation damping (ORD). The sensor architecture incorporates an amorphous silicon (a-Si) substrate and silver metal (Ag) along with tellurium dioxide (TeO₂) as an absorption enhancement layer. Utilizing the dynamic nature of ORD, the quantitative analysis is carried out to observe the contribution of individual layers, their respective thicknesses, and operating wavelength towards absorption enhancement and optimization of figure of merit (FOM). The results are further explained in terms of physical concepts such as power loss, field enhancement, and Rayleigh scattering in the sensors. The systematic optimization of thickness and wavelength led to a maximum FOM of 15,810 RIU⁻¹ with an extremely small FWHM (width of spectrum) of 0.012°. The calculated power loss ratio (PLR) is 6.039 with combined performance factor (CPF) of 92337 μm⁴/RIU. After optimization, the PLR enhances by nearly five times to the initial values. A high PLR and FOM values show ultrasensitive detection, while a small FWHM shows well detectable sensing of malignancy in liver tissues. To the best of our knowledge, the exploitation of ORD for the detection of liver malignancy using ZBLAN fiber, NaF cladding, and an a-Si/Ag/TeO₂ heterostructure has been explored for the first time.

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利用光纤SPR生物传感器增强肝癌近红外传感性能

本文对基于ZBLAN光纤的近红外波段SPR传感器进行了理论和计算研究。将恶性肝组织作为分析物，在最佳辐射阻尼（ORD）现象下进行分析。传感器结构采用非晶硅（a-Si）衬底和银金属（Ag）以及二氧化碲（TeO₂）作为吸收增强层。利用ORD的动态特性，进行定量分析，观察各个层、各自的厚度和工作波长对吸收增强和优值图（FOM）优化的贡献。结果进一步解释了物理概念，如功率损耗，场增强和瑞利散射的传感器。对厚度和波长进行系统优化，最大FOM为15,810 RIU−1，FWHM（谱宽）极小，仅为0.012°。功率损耗比（PLR）为6.039，综合性能因子（CPF）为92337 μm4/RIU。优化后的PLR比初始值提高了近5倍。高PLR和FOM值显示出超灵敏的检测，而小FWHM显示出对肝组织恶性肿瘤的良好检测。据我们所知，利用ZBLAN光纤、NaF包层和a-Si/Ag/TeO 2异质结构，利用ORD检测肝脏恶性肿瘤是首次探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Plasmonics 工程技术-材料科学：综合

CiteScore

5.90

自引率

6.70%

发文量

164

审稿时长

2.1 months

期刊介绍： Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.