Urothelial carcinoma in situ of the entire urinary tract with invasion into seminal vesicle: A case report

Abstract

Urothelial carcinoma in situ represents a high-grade, high-risk form of urothelial cancer which predominantly occurs within the bladder, rarely affecting other structures within the genitourinary system such as the seminal vesicle. Involvement could represent more advanced disease, necessitating more aggressive management. We present a case of CIS involving the entire urinary tract in a renal transplant patient who underwent a complete urinary tract extirpation (CUTE) for BCG-refractory CIS of the bladder. This case is unique, representing the first reported CUTE with malignant involvement of every site in the urinary tract.