Energy-efficient copper-catalyzed synthesis of N-aryl anthranilic acids using concentrated solar radiation

Abstract

N-Aryl anthranilic acids play a crucial role in synthetic chemistry due to their pharmaceutical applications. An environmentally sustainable approach has been developed for the copper-catalyzed synthesis of N-aryl anthranilic acids, utilizing concentrated solar radiation (CSR) as a renewable energy source under aqueous and solvent-free conditions. This method enables the expeditious and selective synthesis of N-aryl anthranilic acids, achieving yields of up to 93 % under mild conditions. Furthermore, the synthetic applicability of the current method is demonstrated by synthesizing pharmaceutical compounds such as tolfenamic acid and mefenamic acid on a gram scale. This method substantially reduces energy consumption by 79–97 % compared to conventional approaches. This eco-friendly method presents a promising alternative to traditional synthesis techniques, highlighting the potential of CSR in advancing sustainable chemical processes.