Genetic evidence for a causal relationship between oral bacterial taxa and asthma in east Asian population

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-09-01 DOI:10.1016/j.cyto.2025.157021

Wenyan Wei , Zejing Qiu , Lu Xiao , Yanlin Huang , Min Chen

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引用次数: 0

Abstract

Background

Emerging evidence highlights the significant role of microbiota (lung and gut) in the development of asthma. However, the potential effect between oral microbiota and asthma remains poorly understood.

Methods

This study performed a bidirectional Mendelian randomization (MR) study using summary statistics from the genome-wide association studies of oral microbiota, immune cell traits and asthma. Various MR analysis methods were employed, including inverse variance weighted (IVW), constrained maximum likelihood model averaging-based method (cML-MA-BIC), maximum likelihood (ML), weighted mode, weighted median, and MR-robust adjusted profile score (MR-RAPS). Additionally, mediation analyses were performed to identify the immune cell traits that mediate these effects.

Results

This study identified 12 oral bacterial taxa and 36 inflammatory cytokines associated with asthma. After identifying the oral microbiota and immune cell characteristics associated with asthma, we applied a mediation MR framework to investigate whether immune cell traits mediate the effect of microbiota on asthma. Finally, we identified eight immune cell traits that mediate asthma caused by bacteria.

Conclusions

Our results highlight the causal associations between oral bacterial taxa, immune cell traits, and asthma, providing evidence that various immune cell traits serve as critical mediators between the oral microbiota and asthma. The link between the oral microbiome and asthma has important implications for clinical practice.

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东亚人群口腔细菌分类群与哮喘因果关系的遗传证据

新出现的证据强调了微生物群（肺和肠道）在哮喘发展中的重要作用。然而，口服微生物群与哮喘之间的潜在影响仍然知之甚少。方法本研究采用双向孟德尔随机化（MR）研究，利用口腔微生物群、免疫细胞特征和哮喘全基因组关联研究的汇总统计数据。采用了各种磁共振分析方法，包括逆方差加权（IVW）、基于约束的最大似然模型平均方法（cML-MA-BIC）、最大似然（ML）、加权模式、加权中位数和磁共振稳健调整剖面评分（MR- raps）。此外，还进行了中介分析，以确定介导这些影响的免疫细胞特性。结果本研究鉴定出12个口腔细菌分类群和36个与哮喘相关的炎症因子。在确定与哮喘相关的口腔微生物群和免疫细胞特征后，我们应用中介MR框架来研究免疫细胞特征是否介导微生物群对哮喘的影响。最后，我们确定了介导由细菌引起的哮喘的8种免疫细胞特征。结论口腔细菌类群、免疫细胞特性与哮喘之间存在因果关系，表明多种免疫细胞特性在口腔微生物群与哮喘之间起着重要的调节作用。口腔微生物组与哮喘之间的联系对临床实践具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.