Perfil clínico y factores de riesgo identificados en pacientes con cáncer renal en población mexicana

IF 1.2 4区医学 Q3 UROLOGY & NEPHROLOGY

Actas urologicas espanolas Pub Date : 2025-09-01 DOI:10.1016/j.acuro.2025.501814

G. Sánchez-Villaseñor , E.A. Pérez-Du Pond , I. Jasso-García , S.J. Vázquez-Sánchez , R.C. García-Romero , J.P. Gómez-Sierra , M.G. Castillo Cardiel , A.S. Álvarez-Villaseñor , G. Cervantes-Guevara , E. Cervantes-Pérez , S. Ramírez-Ochoa , A. González-Ojeda , C. Fuentes-Orozco

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引用次数: 0

Abstract

Introduction

Renal cell carcinoma, ranked 14th in global incidence, is more common in men. Its incidence rates increase with age, peaking in individuals older than 75 years. The classic triad is present in only 17% of cases. Surgical management involves total or partial nephrectomy, both associated with potential complications.

Objective

To identify the clinical profile and risk factors in patients with renal cell carcinoma.

Methodology

An observational, cross-sectional, and analytical study was conducted on patients with renal cell carcinoma treated surgically in the Urology Department from January 2020 to June 2023. Demographic and clinical characteristics were analyzed in relation to TNM staging, histologic subtype, and morbidity and mortality.

Results

Among 83 patients, 48 (57%) were men, with a mean age of 59.2 years (SD 10.5). Hypertension (HTN) and obesity were the most frequent comorbidities, each affecting 37 patients (44.6%). Flank pain (37 patients, 44.6%) and hematuria (23 patients, 27.7%) were the most common manifestations. Age > 50 years was associated with advanced stages (P = .003, OR: 5.744, 95% CI: 1.698-19.424), while obesity was associated with a lower risk of advanced stages (P = .0042, OR: 0.220, 95% CI: 0.075-0.648). Complications of open nephrectomy included bleeding in 26 patients (38.8%) and organ injury in 2 patients (2.9%). Mortality was reported in 1 patient.

Conclusion

Age > 50 years is a risk factor for advanced stages, while obesity is associated with a lower risk. Hematuria and flank pain were common, whereas abdominal mass was rarely reported.

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墨西哥人口中肾癌患者的临床概况和确定的危险因素

肾细胞癌在全球发病率中排名第14位，多见于男性。其发病率随着年龄的增长而增加，在75岁以上的人群中达到高峰。典型的三联征只出现在17%的病例中。手术治疗包括全部或部分肾切除术，两者都有潜在的并发症。目的探讨肾细胞癌的临床特点及危险因素。方法对2020年1月至2023年6月泌尿外科肾细胞癌手术患者进行观察性、横断面性和分析性研究。分析人口统计学和临床特征与TNM分期、组织学亚型、发病率和死亡率的关系。结果83例患者中，男性48例（57%），平均年龄59.2岁（SD 10.5）。高血压（HTN）和肥胖是最常见的合并症，各影响37例（44.6%）。腹部疼痛（37例，44.6%）和血尿（23例，27.7%）是最常见的表现。年龄50岁与晚期相关（P = 0.003, OR: 5.744, 95% CI: 1.698-19.424），而肥胖与晚期风险较低相关（P = 0.0042, OR: 0.220, 95% CI: 0.075-0.648）。开放性肾切除术并发症为出血26例（38.8%），脏器损伤2例（2.9%）。死亡1例。结论50岁是晚期糖尿病的危险因素，而肥胖的风险较低。血尿和腹部疼痛是常见的，而腹部肿块很少报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Actas urologicas espanolas UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

46 days

期刊介绍： Actas Urológicas Españolas is an international journal dedicated to urological diseases and renal transplant. It has been the official publication of the Spanish Urology Association since 1974 and of the American Urology Confederation since 2008. Its articles cover all aspects related to urology. Actas Urológicas Españolas, governed by the peer review system (double blinded), is published online in Spanish and English. Consequently, manuscripts may be sent in Spanish or English and bidirectional free cost translation will be provided.