Cuatro décadas de experiencia con la cefalea en racimos: descripción de una serie de un hospital de tercer nivel

IF 3.1 4区医学 Q2 CLINICAL NEUROLOGY

Neurologia Pub Date : 2025-09-01 DOI:10.1016/j.nrl.2023.01.005

J. Madera, S. Pérez Pereda, V. González Quintanilla, A. González Suárez, E. Benito, J. Pascual

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Abstract

Introduction

There are practically no series of cluster headache (CH) in our country. Our aim was to longitudinally describe the characteristics of patients with CH seen in our Hospital since 1980.

Methods

Retrospective analysis of the clinical charts of patients diagnosed as CH.

Results

We included 153 patients diagnosed as CH. 137 (89,5%) males, with a mean age (MA) at diagnosis of 39.5 years (mean deviation 11.4) and a MA at the beginning of the symptoms of 32.8 years (mean deviation 11.3). 128 suffered from episodic CH (eCH; 92.2% males) and 25 chronic CH (cCH; 76% males). The MA at the beginning was delayed in cCH as compared with eCH (37.6 versus 31.8; P=.023). Four patients (2.6%) had familial antecedents. Only 3 (2%) referred to visual aura. At diagnosis, 66% were smokers and 15% heavy alcohol drinkers. The median duration of cluster period was 60 days, with a median frequency of every 2 years. 16 cases (10.5%) presented a benign course with only one cluster period.

Conclusions

The minimal prevalence of CH in our area was 0.05%, with eCH being the most frequent phenotype. Up to one out of 10 patients showed a benign form with just one cluster period. The diagnostic delay close to 7 years indicates an insufficient recognition of this entity. A high proportion of CH patients showed, already at diagnosis, unhealthy life habits. Cluster periods lasted an average of 2 months and occurred approximately every 2 years. A late beginning and being a woman were associated with the variant of cCH.

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四十年的集束性头痛经验：三级医院系列描述

在我国几乎没有丛集性头痛（CH）系列病例。我们的目的是纵向描述自1980年以来在我院就诊的CH患者的特征。方法回顾性分析诊断为CH的患者的临床资料。结果153例诊断为CH的患者中，男性137例（89.5%），诊断时平均年龄（MA）为39.5岁（平均偏差11.4），症状开始时平均年龄（MA）为32.8岁（平均偏差11.3）。128例发作性CH（男性占92.2%），25例慢性CH（男性占76%）。与eCH相比，cCH开始时的MA延迟（37.6比31.8；P= 0.023）。4例患者（2.6%）有家族病史。仅有3例（2%）涉及视觉先兆。确诊时，66%为吸烟者，15%为重度饮酒者。聚类期的中位数持续时间为60天，中位数频率为每2年一次。16例（10.5%）为良性病程，仅有1个聚集期。结论我区CH的最低患病率为0.05%，其中eCH是最常见的表型。高达十分之一的患者表现为良性形式，只有一个群集期。诊断延迟近7年表明对该实体的认识不足。高比例的CH患者在诊断时就表现出不健康的生活习惯。聚集期平均持续2个月，大约每2年发生一次。出生较晚和女性与cCH变异有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologia 医学-临床神经学

CiteScore

5.90

自引率

2.60%

发文量

135

审稿时长

48 days

期刊介绍： Neurología es la revista oficial de la Sociedad Española de Neurología y publica, desde 1986 contribuciones científicas en el campo de la neurología clínica y experimental. Los contenidos de Neurología abarcan desde la neuroepidemiología, la clínica neurológica, la gestión y asistencia neurológica y la terapéutica, a la investigación básica en neurociencias aplicada a la neurología. Las áreas temáticas de la revistas incluyen la neurologia infantil, la neuropsicología, la neurorehabilitación y la neurogeriatría. Los artículos publicados en Neurología siguen un proceso de revisión por doble ciego a fin de que los trabajos sean seleccionados atendiendo a su calidad, originalidad e interés y así estén sometidos a un proceso de mejora. El formato de artículos incluye Editoriales, Originales, Revisiones y Cartas al Editor, Neurología es el vehículo de información científica de reconocida calidad en profesionales interesados en la neurología que utilizan el español, como demuestra su inclusión en los más prestigiosos y selectivos índices bibliográficos del mundo.