Extracellular Vesicles: A New Dimension in Nerve Injury Repair

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering Pub Date : 2025-08-30 DOI:10.1016/j.eng.2025.08.031

Miaomei Yu, Yang Yu, Jiayi Zhou, Jiang Wei, Liuchang Song, Jun Zhang, Lu Zheng, Fei Ding

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引用次数: 0

Abstract

Peripheral and central nerve injuries present significant challenges in clinical practice due to the paucity of effective therapeutic options. Extracellular vesicles (EVs), lipid membrane-encapsulated nanoparticles released from most cell types, are enriched in bioactive molecules capable of mediating intercellular communication. Recently, EVs have shown potential for applications in regenerative medicine, notably as alternatives to cell therapy. A therapeutic paradigm shift is emerging towards the EV-based treatment of nerve injury. Accumulating evidence indicates that EVs promote nerve regeneration and functional recovery, primarily by modulating neural cell function, immune-inflammatory responses, and angiogenesis. Various strategies have been developed to incorporate EVs into nerve grafts or to utilize them as diagnostic and therapeutic vehicles. This review aimed to provide a systematic survey of the available literature on the latest progress in EV-based treatments for peripheral nerve, spinal cord, and brain injuries. Additionally, prospects of EV-based nerve injury repair are discussed in terms of deep mechanistic understanding, technological innovations, and interdisciplinary convergence.

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细胞外囊泡：神经损伤修复的新方向

由于缺乏有效的治疗选择，外周和中枢神经损伤在临床实践中提出了重大挑战。细胞外囊泡（EVs）是大多数细胞类型释放的脂质膜包裹的纳米颗粒，富含能够介导细胞间通讯的生物活性分子。最近，电动汽车已经显示出在再生医学中的应用潜力，特别是作为细胞治疗的替代品。一种治疗模式的转变正在向以ev为基础的神经损伤治疗方向发展。越来越多的证据表明，ev主要通过调节神经细胞功能、免疫炎症反应和血管生成来促进神经再生和功能恢复。已经开发了各种策略将ev纳入神经移植物或将其用作诊断和治疗载体。本综述旨在系统地综述以ev为基础治疗周围神经、脊髓和脑损伤的最新进展。此外，本文还从深层机制理解、技术创新和跨学科融合等方面讨论了基于电动汽车的神经损伤修复的前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Engineering Environmental Science-Environmental Engineering

自引率

1.60%

发文量

335

审稿时长

35 days

期刊介绍： Engineering, an international open-access journal initiated by the Chinese Academy of Engineering (CAE) in 2015, serves as a distinguished platform for disseminating cutting-edge advancements in engineering R&D, sharing major research outputs, and highlighting key achievements worldwide. The journal's objectives encompass reporting progress in engineering science, fostering discussions on hot topics, addressing areas of interest, challenges, and prospects in engineering development, while considering human and environmental well-being and ethics in engineering. It aims to inspire breakthroughs and innovations with profound economic and social significance, propelling them to advanced international standards and transforming them into a new productive force. Ultimately, this endeavor seeks to bring about positive changes globally, benefit humanity, and shape a new future.