Eco-friendly Biginelli reaction via copper–chitosan catalyst

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2025-06-26 DOI:10.1007/s11164-025-05645-x

Magda H. Abdellattif, Chou-Yi Hsu, Munthar Kadhim Abosaoda, Ashok Kumar Bishoyi, Suhas Ballal, Manal Morad Karim, Abhayveer Singh, S. Supriya, Rajashree Panigrahi

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引用次数: 0

Abstract

In this study, one of the most unique green catalysts named Cu-Picolin-Chitosan-mTEG was designed, synthesized and analyzed using different methods such as XRD, FESEM, TEM, TGA, FTIR, EDX-EDS, DLS, and ICP analyses. After confirming of synthesized nanocomposite, it is tested in oxidation of various alcohols to aldehyde and the insitu formed aldehydes are condensed with thiourea and 4‑hydroxycumarin. Finally, the synthesis of nine new thioxochromenopyrimidine derivatives by Cu-Picolin-Chitosan-mTEG is examined in perfect yields from alcohol derivatives. The conditions for reaction are green, and water is used as a solvent. This protocol offers several notable advantages, such as cost-effectiveness, atom economy, low catalyst loading, green oxidants, mild conditions, high yields, and recyclability of the nanocomposite over five cycles. Notably, this is the first report on the use of this nanocomposite for the synthesis of thioxochromenopyrimidine derivatives.

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铜-壳聚糖催化的环保Biginelli反应

本研究设计、合成了一种独特的绿色催化剂Cu-Picolin-Chitosan-mTEG，并采用XRD、FESEM、TEM、TGA、FTIR、EDX-EDS、DLS、ICP等分析方法对其进行了分析。在确定合成的纳米复合材料后，对其进行了各种醇氧化制醛的测试，并将原位生成的醛与硫脲和4 -羟基茴香素缩合。最后，研究了用cu - picolin -壳聚糖- mteg合成九种新型硫代铬膜嘧啶衍生物的最佳产率。反应条件为绿色，以水为溶剂。该方案具有成本效益、原子经济性、低催化剂负载、绿色氧化剂、温和的条件、高收率和5个循环的可回收性等显著优势。值得注意的是，这是首次报道将该纳米复合材料用于合成硫代铬膜嘧啶衍生物。

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.