Mathematical Modeling of Radiation-Induced Effects in the Structures of the Central Nervous System under the Action of Accelerated Heavy Charged Particles
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引用次数: 0
Abstract
The article presents the theoretical research results of the basic mechanisms of action of accelerated heavy charged particles on the structures of the central nervous system considering their complex geometry. An analysis is performed of spatial distribution regularities of absorbed dose and the probability of hitting different parts of the cell by particles (body, axon, dendrites, spines) when irradiated with charged particles—from protons to iron ions with energies ranging from 10 to 1000 MeV/nucleon. Reactions leading to the formation of both direct and indirect molecular damage in the genetic apparatus and synapses of neurons are considered, involving physical processes that lead to bond rupture as well as chemical reactions with water radiolysis products. The main modeling parameters needed to verify the calculations using experimental results are also discussed. The data can be used for further analysis of radiation risks during interplanetary missions, as well as for evaluating the side effects of hadron therapy.
期刊介绍:
The journal Fizika Elementarnykh Chastits i Atomnogo Yadr of the Joint Institute for Nuclear Research (JINR, Dubna) was founded by Academician N.N. Bogolyubov in August 1969. The Editors-in-chief of the journal were Academician N.N. Bogolyubov (1970–1992) and Academician A.M. Baldin (1992–2001). Its English translation, Physics of Particles and Nuclei, appears simultaneously with the original Russian-language edition. Published by leading physicists from the JINR member states, as well as by scientists from other countries, review articles in this journal examine problems of elementary particle physics, nuclear physics, condensed matter physics, experimental data processing, accelerators and related instrumentation ecology and radiology.