Mathematical Modeling of Radiation-Induced Effects in the Structures of the Central Nervous System under the Action of Accelerated Heavy Charged Particles

IF 0.5 4区 物理与天体物理 Q4 PHYSICS, PARTICLES & FIELDS
M. Batmunkh, L. Bayarchimeg, A. N. Bugay
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引用次数: 0

Abstract

The article presents the theoretical research results of the basic mechanisms of action of accelerated heavy charged particles on the structures of the central nervous system considering their complex geometry. An analysis is performed of spatial distribution regularities of absorbed dose and the probability of hitting different parts of the cell by particles (body, axon, dendrites, spines) when irradiated with charged particles—from protons to iron ions with energies ranging from 10 to 1000 MeV/nucleon. Reactions leading to the formation of both direct and indirect molecular damage in the genetic apparatus and synapses of neurons are considered, involving physical processes that lead to bond rupture as well as chemical reactions with water radiolysis products. The main modeling parameters needed to verify the calculations using experimental results are also discussed. The data can be used for further analysis of radiation risks during interplanetary missions, as well as for evaluating the side effects of hadron therapy.

Abstract Image

Abstract Image

加速重带电粒子作用下中枢神经系统结构辐射诱导效应的数学建模
本文介绍了加速重带电粒子在复杂几何结构下对中枢神经系统结构作用的基本机理的理论研究结果。分析了吸收剂量的空间分布规律和粒子(体、轴突、树突、棘)在质子、铁离子等带电粒子(能量从10 - 1000 MeV/核子不等)照射下撞击细胞不同部位的概率。考虑了导致遗传装置和神经元突触形成直接和间接分子损伤的反应,包括导致键断裂的物理过程以及与水溶产物的化学反应。讨论了用实验结果验证计算结果所需的主要建模参数。这些数据可用于进一步分析行星际任务期间的辐射风险,以及评估强子治疗的副作用。
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来源期刊
Physics of Particles and Nuclei
Physics of Particles and Nuclei 物理-物理:粒子与场物理
CiteScore
1.00
自引率
0.00%
发文量
116
审稿时长
6-12 weeks
期刊介绍: The journal Fizika Elementarnykh Chastits i Atomnogo Yadr of the Joint Institute for Nuclear Research (JINR, Dubna) was founded by Academician N.N. Bogolyubov in August 1969. The Editors-in-chief of the journal were Academician N.N. Bogolyubov (1970–1992) and Academician A.M. Baldin (1992–2001). Its English translation, Physics of Particles and Nuclei, appears simultaneously with the original Russian-language edition. Published by leading physicists from the JINR member states, as well as by scientists from other countries, review articles in this journal examine problems of elementary particle physics, nuclear physics, condensed matter physics, experimental data processing, accelerators and related instrumentation ecology and radiology.
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