Putamen vascularization on high-resolution 7T MRI is associated with perfusion and cognitive performance in cerebral small vessel disease

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-08-22 DOI:10.1016/j.neuroimage.2025.121426

Philipp Arndt , Stefanie Boewe , Jascha Brüggemann , Berta Garcia-Garcia , Renat Yakupov , Niklas Vockert , Anne Maas , Malte Pfister , Valentina Perosa , Marwa Al Dubai , Robin Jansen , Sven G. Meuth , Marc Dörner , Patrick Müller , Solveig Henneicke , Frank Schreiber , Katja Neumann , Hendrik Mattern , Stefanie Schreiber

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引用次数: 0

Abstract

Objective

In cerebral small vessel disease (CSVD), compromised arterial supply to the deep gray matter contributes to cognitive decline. While CSVD frequently involves lenticulostriate arteries supplying the putamen, the functional consequences of altered putaminal vascular architecture remain unclear. We hypothesized that a less homogeneous arterial network in the putamen is associated with impaired perfusion and worse cognitive performance in CSVD.

Methods

We enrolled 16 CSVD patients with cerebral microbleeds and 21 age‑matched controls (mean age 71 years; 38 % female). High-resolution 7 T time‑of‑flight angiography was used to segment all visible intraputaminal vessels. For each voxel in the putamen, the distance to its nearest segmented vessel was computed to generate a vessel distance map; the mean vessel distance reflects the homogeneity of the arterial network. Putaminal perfusion was quantified via multi‑inversion time pulsed arterial spin labeling (ASL) at 3 T, and CSVD severity was scored on clinical 3 T MRI. All participants completed a comprehensive neuropsychological battery to derive a global cognition composite score.

Results

Linear regression revealed that higher CSVD MRI scores predicted larger mean vessel distance, reflecting a sparser arterial network, in both the right (B = 0.12, β = 0.42, p = 0.010) and left putamen (B = 0.13, β = 0.43, p = 0.014). Across all participants, increased vessel distance was also associated with prolonged arterial transit time in the right (B = 0.044, β = 0.50, p = 0.009) and left putamen (B = 0.042, β = 0.49, p = 0.009). Finally, in a multivariable linear regression adjusting for demographics, vascular risk factors, and CSVD severity, greater vessel distance in the right putamen was associated with lower global cognitive performance (B = –1.26, β = –0.34, p = 0.012).

Conclusion

This study demonstrates the impact of an impaired arterial network in the putamen on blood supply and cognitive function across the continuum of CSVD.

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高分辨率7T MRI上的壳核血管化与脑小血管疾病的灌注和认知能力相关

目的在脑血管病（CSVD）中，动脉深灰质供应受损是认知能力下降的原因之一。虽然CSVD经常涉及供应壳核的荚状纹状动脉，但壳核血管结构改变的功能后果尚不清楚。我们假设壳核动脉网络不均匀与心血管疾病患者灌注受损和认知能力下降有关。方法我们招募了16例伴有脑微出血的CSVD患者和21例年龄匹配的对照组（平均年龄71岁，女性占38%）。高分辨率7t飞行时间血管造影用于分割所有可见的壳内血管。对于壳核中的每个体素，计算其到最近的分割血管的距离，生成血管距离图；平均血管距离反映了动脉网络的均匀性。在3t时通过多逆时间脉冲动脉自旋标记（ASL）量化皮膜灌注，并在临床3t MRI上对CSVD严重程度进行评分。所有参与者都完成了一个全面的神经心理学测试，以得出一个整体认知综合评分。结果线性回归显示，CSVD MRI评分越高，右侧（B = 0.12, β = 0.42, p = 0.010）和左侧壳核（B = 0.13, β = 0.43, p = 0.014）的平均血管距离越大，反映动脉网络越稀疏。在所有参与者中，血管距离的增加也与右侧（B = 0.044, β = 0.50, p = 0.009）和左侧壳核（B = 0.042, β = 0.49, p = 0.009）动脉运输时间的延长有关。最后，在调整人口统计学、血管危险因素和CSVD严重程度的多变量线性回归中，右侧壳核血管距离越远，整体认知能力越低（B = -1.26, β = -0.34, p = 0.012）。结论：本研究证明了壳核动脉网络受损对心血管疾病连续体血液供应和认知功能的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.