Graphene nanoribbons: A cutting-edge material for the point-of-care cancer biomarker detection

IF 4.9 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Sensors and Actuators A-physical Pub Date : 2025-08-25 DOI:10.1016/j.sna.2025.117007

Jincymol Kappen , Katarzyna Krukiewicz

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引用次数: 0

Abstract

Graphene nanoribbons (GNRs), being quasi-one-dimensional strips of single-layer graphene, are a fascinating material among the others in the graphene family due to their unique edge and width-oriented semiconducting properties. Possible to be formed using both the top-down and bottom-up synthesis routes, GNRs are available in numerous forms, including zig-zag, armchair, chiral, chevron, cove, and gulf structures, each resulting in an exceptional set of physicochemical properties suitable for a variety of specific applications. Recent research has shown the exceptional applicability of GNRs in the biomedical field, since the possibility of covalent and non-covalent functionalization of GNRs generates an excellent platform for the immobilization of biological molecules and their biosensing, also those present in ultra-low quantities. This systematic review aims to present the potential of GNRs in the field of the electrochemical detection of cancer biomarkers, which should be identified as early as possible for the accurate diagnosis and prognosis. After providing a concise introduction to GNRs, including their classification, properties, and synthesis routes, this review discusses recent developments in GNRs-based point-of-care detection methods, highlighting their great potential in biosensing and enlightening their prospects in future research.

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石墨烯纳米带：用于即时癌症生物标志物检测的尖端材料

石墨烯纳米带（gnr）是单层石墨烯的准一维条带，由于其独特的边缘和面向宽度的半导体特性，在石墨烯家族中是一种令人着迷的材料。gnr可以采用自顶向下和自底向上的合成路线形成，有多种形式，包括之字形、扶手椅、手性、chevron、cove和gulf结构，每种结构都有一组特殊的物理化学性质，适用于各种特定应用。最近的研究表明，gnr在生物医学领域具有特殊的适用性，因为gnr的共价和非共价功能化的可能性为生物分子的固定化及其生物传感提供了一个极好的平台，也包括那些超低量的生物分子。本文旨在介绍gnr在电化学检测癌症生物标志物领域的潜力，尽早发现这些标志物，以便准确诊断和预后。本文简要介绍了GNRs的分类、性质和合成途径，讨论了基于GNRs的即时检测方法的最新进展，强调了其在生物传感方面的巨大潜力，并对其未来的研究前景进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...