Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): About three case reports

IF 1.3 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports Pub Date : 2025-08-26 DOI:10.1016/j.gore.2025.101932

J. Benichou , J. Varinot , R. Bossi-Croci , M. Bazot , D. Sitbon , M. Dahan , C. Ferrier , Y. Dabi , C. Touboul , J. Lotz , E. Darai

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Abstract

Background

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is an extremely rare and aggressive ovarian cancer affecting young women, typically associated with poor survival. We present three cases of SCCOHT and review the current literature regarding clinical features, diagnosis, management, and survival.

Cases

Three patients aged 16, 29, and 39 years were treated for ovarian masses. None presented with hypercalcemia. In case 1, MRI findings mimicked a mucinous cystadenocarcinoma, while the other two cases appeared as benign ovarian tumors. Following initial surgery and histological diagnosis of SCCOHT, all patients received comprehensive radical surgery, multi-agent chemotherapy, radiotherapy, and autologous stem cell transplantation. Two patients remain recurrence-free at 5 and 20 years, while the third has a 10-month follow-up. Genetic testing was performed in two patients, revealing no constitutional mutations in SMARCA4 or related genes.

Conclusions

These cases highlight the difficulty of establishing a preoperative diagnosis of SCCOHT. Unlike previous reports, our data suggest that intensive multimodal therapy can result in favourable outcomes for stage I SCCOHT. Further studies are needed to define optimal treatment strategies.

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卵巢高钙血症型小细胞癌（scoht）：约3例报告

背景：卵巢小细胞癌，高钙血症型（scoht），是一种非常罕见的侵袭性卵巢癌，影响年轻女性，通常与低生存率相关。我们报告了3例scot病例，并回顾了目前关于临床特征、诊断、治疗和生存的文献。3例患者年龄分别为16岁、29岁和39岁。没有出现高钙血症。病例1 MRI表现为粘液囊腺癌，而其他2例表现为良性卵巢肿瘤。经初步手术及组织学诊断后，所有患者均接受全面根治性手术、多药化疗、放疗及自体干细胞移植。两名患者在5年和20年仍然没有复发，而第三名患者进行了10个月的随访。两名患者进行了基因检测，未发现SMARCA4或相关基因的结构突变。结论这些病例突出了scot术前诊断的困难。与以前的报道不同，我们的数据表明，强化多模式治疗可导致I期scot的良好结果。需要进一步的研究来确定最佳的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic Oncology Reports OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

183

审稿时长

41 days

期刊介绍： Gynecologic Oncology Reports is an online-only, open access journal devoted to the rapid publication of narrative review articles, survey articles, case reports, case series, letters to the editor regarding previously published manuscripts and other short communications in the field of gynecologic oncology. The journal will consider papers that concern tumors of the female reproductive tract, with originality, quality, and clarity the chief criteria of acceptance.