C20orf27 regulates colorectal cancer growth and metastasis based on different lipid levels

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-08-26 DOI:10.1016/j.cellsig.2025.112082

Peng Xu , Haidi Guan , Guangsheng Du , Zhongwei Xu , Dong Xiong , Weidong Xiao , Xiufei Liu , Lihua Sun

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引用次数: 0

Abstract

Colorectal cancer (CRC) is a high-incidence malignant tumor that lacks highly effective targeted treatments currently. Epidemiology studies have revealed a direct association between high-fat diet intake and CRC. C20orf27, a key factor controlling adipose thermogenesis and glucose homeostasis, is abnormally overexpressed in CRC. However, its roles in CRC remain unknown. Therefore, our study aimed to reveal the clinical significance and biological function of C20orf27 in human CRC. Here, C20orf27 expression showed a positive correlation with patient body mass index values. Furthemore, we have demonstrated that C20orf27 promotes tumor proliferation while suppressing metastasis in CRC cells. However, under high-lipid induction conditions, C20orf27 exhibits paradoxical effects-inhibiting proliferation but enhancing metastatic potential in CRC cells. Moreover, we revealed that C20orf27 mediated CRC cell proliferation and metastasis through different signaling pathways (XBP1 or MST1) in the presence or absence of hyperlipidemia. In conclusion, our study showed the unique tumorigenic properties of C20orf27 in regulating CRC development and delineated the underlying mechanism by which it is affected by the lipid environment.

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C20orf27基于不同脂质水平调控结直肠癌的生长和转移

结直肠癌（CRC）是一种高发恶性肿瘤，目前缺乏高效的靶向治疗方法。流行病学研究揭示了高脂肪饮食摄入与结直肠癌之间的直接联系。C20orf27是控制脂肪产热和葡萄糖稳态的关键因子，在结直肠癌中异常过表达。然而，其在CRC中的作用尚不清楚。因此，我们的研究旨在揭示C20orf27在人结直肠癌中的临床意义和生物学功能。C20orf27表达与患者体重指数呈正相关。此外，我们已经证明C20orf27促进肿瘤增殖，同时抑制CRC细胞的转移。然而，在高脂诱导条件下，C20orf27在CRC细胞中表现出矛盾的作用-抑制增殖但增强转移潜力。此外，我们发现在存在或不存在高脂血症的情况下，C20orf27通过不同的信号通路（XBP1或MST1）介导CRC细胞增殖和转移。总之，我们的研究显示了C20orf27在调节结直肠癌发展中的独特致瘤特性，并描绘了其受脂质环境影响的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.