{"title":"Developmental Origins of the Heterogeneous Hematopoiesis","authors":"Shaokang Mo, Kuangyu Yen","doi":"10.1002/ajh.70050","DOIUrl":null,"url":null,"abstract":"Hematopoietic stem and progenitor cells (HSPCs) are initially generated during embryogenesis, laying the foundation for the hematopoietic system. These embryonic HSPCs exhibit functional heterogeneity, which is essential for their diverse roles in both fetal and adult hematopoiesis. Growing evidence suggests that this heterogeneity arises from hemogenic endothelium (HE), a specialized subset of endothelial precursors with hematopoietic potential. Additionally, studies show that hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) emerge independently from HE, with notable contributions from non‐endothelial sources. This review explores the spatiotemporal heterogeneity of HE and discusses how this diversity contributes to the emergence of HSPCs. We propose an integrated framework that refines current models by highlighting the regional and temporal variations in HE that drive HSPC diversification. By synthesizing current knowledge, this review offers novel insights into the origins of hematopoietic diversity and the factors that govern HE differentiation.","PeriodicalId":7724,"journal":{"name":"American Journal of Hematology","volume":"1 1","pages":""},"PeriodicalIF":9.9000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Hematology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/ajh.70050","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Hematopoietic stem and progenitor cells (HSPCs) are initially generated during embryogenesis, laying the foundation for the hematopoietic system. These embryonic HSPCs exhibit functional heterogeneity, which is essential for their diverse roles in both fetal and adult hematopoiesis. Growing evidence suggests that this heterogeneity arises from hemogenic endothelium (HE), a specialized subset of endothelial precursors with hematopoietic potential. Additionally, studies show that hematopoietic stem cells (HSCs) and multipotent hematopoietic progenitors (MPPs) emerge independently from HE, with notable contributions from non‐endothelial sources. This review explores the spatiotemporal heterogeneity of HE and discusses how this diversity contributes to the emergence of HSPCs. We propose an integrated framework that refines current models by highlighting the regional and temporal variations in HE that drive HSPC diversification. By synthesizing current knowledge, this review offers novel insights into the origins of hematopoietic diversity and the factors that govern HE differentiation.
期刊介绍:
The American Journal of Hematology offers extensive coverage of experimental and clinical aspects of blood diseases in humans and animal models. The journal publishes original contributions in both non-malignant and malignant hematological diseases, encompassing clinical and basic studies in areas such as hemostasis, thrombosis, immunology, blood banking, and stem cell biology. Clinical translational reports highlighting innovative therapeutic approaches for the diagnosis and treatment of hematological diseases are actively encouraged.The American Journal of Hematology features regular original laboratory and clinical research articles, brief research reports, critical reviews, images in hematology, as well as letters and correspondence.