Efficacy of Collagen Sponges and Gelatine Sponges as Dressing for Palatal Wounds: A Randomised Controlled Clinical Trial

IF 6.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2025-08-28 DOI:10.1111/jcpe.70028

Jia‐Ping Huang, Yao Jiang, Xiao‐Yuan Cheng, Jing Wang, Yu‐Han Huang, Anna Dai, Shuai Zhou, Wei‐Yi Pan, Shu‐Lei Fu, Yi‐Yu Wang, Pei‐Hui Ding

{"title":"Efficacy of Collagen Sponges and Gelatine Sponges as Dressing for Palatal Wounds: A Randomised Controlled Clinical Trial","authors":"Jia‐Ping Huang, Yao Jiang, Xiao‐Yuan Cheng, Jing Wang, Yu‐Han Huang, Anna Dai, Shuai Zhou, Wei‐Yi Pan, Shu‐Lei Fu, Yi‐Yu Wang, Pei‐Hui Ding","doi":"10.1111/jcpe.70028","DOIUrl":null,"url":null,"abstract":"AimTo evaluate the clinical outcomes of collagen sponges (CSs) on wound healing following palatal graft harvesting and compare their efficacy with gelatine sponges (GSs).Materials and MethodsThirty‐two participants who had undergone free gingival grafts or de‐epithelialised gingival grafts were randomised into the CS group or the GS group. Wound healing rate was calculated as the percentage of the healed wound area divided by the initial wound area. Wound healing rate and complete epithelialisation were evaluated at 1, 2, 3 and 4 weeks. Postoperative pain was assessed on days 1, 3 and 7. Willingness to repeat graft harvesting, delayed bleeding and aesthetic outcomes were also recorded.ResultsCS group had higher wound healing rates than GS group at 1 and 2 weeks (24.44% ± 6.28% vs. 5.56% ± 2.19%, p < 0.01; 91.54% ± 3.20% vs. 75.56% ± 4.77%, p < 0.05). Complete epithelialisation was achieved within 2–3 weeks in CS group and within 2–4 weeks in GS group, but no significant difference was found. Postoperative pain in VAS was lower in the CS group on Day 1 compared with the GS group (1.6 ± 0.4 vs. 3.1 ± 0.5, p < 0.05). No significant difference could be detected in willingness to repeat graft harvesting, delayed bleeding and aesthetic outcomes.ConclusionsCompared with GS, CS seemed to offer improved early healing and reduced postoperative pain following palatal graft harvesting.Trial RegistrationThis trial was registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2200057221 (https://www.chictr.org.cn/showproj.html?proj=154474) on March 4, 2022","PeriodicalId":15380,"journal":{"name":"Journal of Clinical Periodontology","volume":"23 1","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Periodontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/jcpe.70028","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

AimTo evaluate the clinical outcomes of collagen sponges (CSs) on wound healing following palatal graft harvesting and compare their efficacy with gelatine sponges (GSs).Materials and MethodsThirty‐two participants who had undergone free gingival grafts or de‐epithelialised gingival grafts were randomised into the CS group or the GS group. Wound healing rate was calculated as the percentage of the healed wound area divided by the initial wound area. Wound healing rate and complete epithelialisation were evaluated at 1, 2, 3 and 4 weeks. Postoperative pain was assessed on days 1, 3 and 7. Willingness to repeat graft harvesting, delayed bleeding and aesthetic outcomes were also recorded.ResultsCS group had higher wound healing rates than GS group at 1 and 2 weeks (24.44% ± 6.28% vs. 5.56% ± 2.19%, p < 0.01; 91.54% ± 3.20% vs. 75.56% ± 4.77%, p < 0.05). Complete epithelialisation was achieved within 2–3 weeks in CS group and within 2–4 weeks in GS group, but no significant difference was found. Postoperative pain in VAS was lower in the CS group on Day 1 compared with the GS group (1.6 ± 0.4 vs. 3.1 ± 0.5, p < 0.05). No significant difference could be detected in willingness to repeat graft harvesting, delayed bleeding and aesthetic outcomes.ConclusionsCompared with GS, CS seemed to offer improved early healing and reduced postoperative pain following palatal graft harvesting.Trial RegistrationThis trial was registered in the Chinese Clinical Trial Registry with the registration number ChiCTR2200057221 (https://www.chictr.org.cn/showproj.html?proj=154474) on March 4, 2022

查看原文本刊更多论文

胶原蛋白海绵和明胶海绵作为腭创面敷料的疗效：一项随机对照临床试验

目的评价胶原海绵（CSs）在腭移植术后创面愈合中的临床效果，并与明胶海绵（GSs）进行比较。材料和方法32例接受游离牙龈移植或去上皮化牙龈移植的患者随机分为CS组和GS组。创面愈合率计算为创面愈合面积除以初始创面面积的百分比。分别于1、2、3、4周观察创面愈合率和上皮化程度。术后第1、3、7天评估疼痛。重复移植的意愿，延迟出血和美学结果也被记录。结果scs组创面愈合率高于GS组（24.44%±6.28% vs. 5.56%±2.19%,p < 0.01; 91.54%±3.20% vs. 75.56%±4.77%,p < 0.05）。CS组在2 ~ 3周内完成上皮化，GS组在2 ~ 4周内完成上皮化，差异无统计学意义。CS组术后第1天VAS疼痛低于GS组（1.6±0.4比3.1±0.5,p < 0.05）。在重复移植的意愿、延迟出血和美学结果方面没有显著差异。结论与GS相比，CS似乎可以改善腭移植术后的早期愈合和减少术后疼痛。试验注册本试验于2022年3月4日在中国临床试验注册中心注册，注册号为ChiCTR2200057221 （https://www.chictr.org.cn/showproj.html?proj=154474）

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.