Open Wound Healing in Guided Bone Regeneration Using a Magnesium Membrane: A Paradigm Shift

IF 3.4 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Giorgio Tabanella, Patrick Rider, Svenja Rogge, Marija Čandrlić, Željka Perić Kačarević
{"title":"Open Wound Healing in Guided Bone Regeneration Using a Magnesium Membrane: A Paradigm Shift","authors":"Giorgio Tabanella,&nbsp;Patrick Rider,&nbsp;Svenja Rogge,&nbsp;Marija Čandrlić,&nbsp;Željka Perić Kačarević","doi":"10.1002/jbm.b.35642","DOIUrl":null,"url":null,"abstract":"<p>Guided bone regeneration (GBR) is essential in implant dentistry for managing bone deficiencies. Despite its high success rate, complications like wound dehiscence, membrane exposure, and infection can compromise outcomes. These issues are influenced by patient health, surgical technique, and the implanted biomaterials. Membrane exposure may lead to significant bone loss and jeopardise treatment success. A resorbable magnesium membrane has been recently introduced for GBR, but soft tissue healing complications have not yet been reported. This case series reviews four instances of wound dehiscence to assess its impact on clinical outcomes. Four patients underwent GBR using a magnesium membrane before implant placement. Each followed a similar protocol: defects were filled with bovine and autologous bone, then covered with the magnesium membrane. Membrane exposure occurred in all cases, varying from small to large. However, none experienced pain or signs of infection, and no additional treatment was required. Implant placement proceeded as planned, with no notable bone loss. Despite varying degrees of exposure, the magnesium membrane prevented infection, pain, or significant bone loss. It effectively maintained a barrier between tissues, suggesting its potential to reduce complications from exposure. Larger studies are needed to validate these findings.</p>","PeriodicalId":15269,"journal":{"name":"Journal of biomedical materials research. Part B, Applied biomaterials","volume":"113 9","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jbm.b.35642","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical materials research. Part B, Applied biomaterials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jbm.b.35642","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0

Abstract

Guided bone regeneration (GBR) is essential in implant dentistry for managing bone deficiencies. Despite its high success rate, complications like wound dehiscence, membrane exposure, and infection can compromise outcomes. These issues are influenced by patient health, surgical technique, and the implanted biomaterials. Membrane exposure may lead to significant bone loss and jeopardise treatment success. A resorbable magnesium membrane has been recently introduced for GBR, but soft tissue healing complications have not yet been reported. This case series reviews four instances of wound dehiscence to assess its impact on clinical outcomes. Four patients underwent GBR using a magnesium membrane before implant placement. Each followed a similar protocol: defects were filled with bovine and autologous bone, then covered with the magnesium membrane. Membrane exposure occurred in all cases, varying from small to large. However, none experienced pain or signs of infection, and no additional treatment was required. Implant placement proceeded as planned, with no notable bone loss. Despite varying degrees of exposure, the magnesium membrane prevented infection, pain, or significant bone loss. It effectively maintained a barrier between tissues, suggesting its potential to reduce complications from exposure. Larger studies are needed to validate these findings.

Abstract Image

开放性伤口愈合引导骨再生使用镁膜:范式转变
引导骨再生(GBR)是必不可少的种植牙科管理骨缺乏。尽管成功率很高,但诸如伤口裂开、膜暴露和感染等并发症会影响结果。这些问题受到患者健康、手术技术和植入生物材料的影响。膜暴露可能导致严重的骨质流失,危及治疗成功。可吸收镁膜最近被引入GBR,但软组织愈合并发症尚未报道。本病例系列回顾了四个伤口裂开的实例,以评估其对临床结果的影响。4例患者在植入前使用镁膜进行GBR。每个都遵循类似的程序:用牛骨和自体骨填充缺陷,然后用镁膜覆盖。所有病例均有膜暴露,大小不一。然而,没有人经历疼痛或感染迹象,也不需要额外的治疗。种植体植入按计划进行,无明显骨质流失。尽管暴露程度不同,但镁膜可以防止感染、疼痛或严重的骨质流失。它有效地保持了组织之间的屏障,这表明它有可能减少暴露引起的并发症。需要更大规模的研究来验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信