Eco-friendly NIR fluorescent probe based on xanthene derivatives for ultrafast detection of sulfites in food samples and biological systems

IF 4.2 3区工程技术 Q2 CHEMISTRY, APPLIED

Dyes and Pigments Pub Date : 2025-08-27 DOI:10.1016/j.dyepig.2025.113191

Ruiqi Ren , Mingyu Tian , Jiaxing Li , Xiaomei Yan , Tianyu Liang , Chengyan Wu , Yang Li , Lijun Tang , Keli Zhong

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引用次数: 0

Abstract

Excessive intake of SO₂ and its derivatives in food and environment poses serious threats to human health. Fluorescent molecular imaging probes for the specific detection of sulfites are hindered by poor solubility, which affects the sensitivity to sulfites and limits the range of applications. Here, we developed an eco-friendly near-infrared fluorescent probe XQD-H, by constructing a distinctive “Dual-Positive-Ion” platform to address the above challenges. The typical acceptor-π-acceptor (A−π−A) structure puts XQD-H fluorescence in the dark state, and its specific combination with HSO₃⁻ rapidly transforms from the A−π−A type to the donor-π-acceptor (D−π−A) type to achieve significant fluorescence release. Notably, XQD-H showed excellent optical properties for HSO₃⁻ in aqueous solution, possessing the advantages of ultra-rapid response, high sensitivity, low detection limits, strong resistance to interference and a wide pH range of applicability. In addition, the detection of HSO₃⁻ by the probe XQD-H can also be observed with the naked eye under visible light, offering an easy and intuitive method for detection. The XQD-H has been successfully used for rapid quantitative detection of sulfites in food, water samples and cellular mitochondria. Thus, this cost-effective, rapid-response, and nondestructive portable device presents a promising platform for real-time sulfite detection and make anti-counterfeiting inks.

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基于杂蒽衍生物的环保型近红外荧光探针用于食品样品和生物系统中亚硫酸盐的超快速检测

食物和环境中二氧化硫及其衍生物的过量摄入对人类健康构成严重威胁。用于亚硫酸盐特异性检测的荧光分子成像探针由于溶解度差，影响了亚硫酸盐的灵敏度，限制了其应用范围。在这里，我们通过构建独特的“双正离子”平台来解决上述挑战，开发了一种环保型近红外荧光探针XQD-H。典型的受体-π-受体（A−π−A）结构使XQD-H荧光处于暗态，其与HSO3−的特异性结合使XQD-H荧光从A−π−A型迅速转变为供体-π-受体（D−π−A）型，实现了显著的荧光释放。值得注意的是，XQD-H在水溶液中对HSO3−表现出优异的光学性能，具有超快速响应、灵敏度高、检出限低、抗干扰能力强、适用pH范围广等优点。此外，XQD-H探针对HSO3−的检测也可以在可见光下用肉眼观察到，提供了一种简单直观的检测方法。XQD-H已成功用于食品、水样和细胞线粒体中亚硫酸盐的快速定量检测。因此，这种具有成本效益，快速响应和无损的便携式设备为实时亚硫酸盐检测和制作防伪油墨提供了一个有前途的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dyes and Pigments 工程技术-材料科学：纺织

CiteScore

8.20

自引率

13.30%

发文量

933

审稿时长

33 days

期刊介绍： Dyes and Pigments covers the scientific and technical aspects of the chemistry and physics of dyes, pigments and their intermediates. Emphasis is placed on the properties of the colouring matters themselves rather than on their applications or the system in which they may be applied. Thus the journal accepts research and review papers on the synthesis of dyes, pigments and intermediates, their physical or chemical properties, e.g. spectroscopic, surface, solution or solid state characteristics, the physical aspects of their preparation, e.g. precipitation, nucleation and growth, crystal formation, liquid crystalline characteristics, their photochemical, ecological or biological properties and the relationship between colour and chemical constitution. However, papers are considered which deal with the more fundamental aspects of colourant application and of the interactions of colourants with substrates or media. The journal will interest a wide variety of workers in a range of disciplines whose work involves dyes, pigments and their intermediates, and provides a platform for investigators with common interests but diverse fields of activity such as cosmetics, reprographics, dye and pigment synthesis, medical research, polymers, etc.