Three-component redox-neutral alkene difunctionalization by radical copper catalysis

Abstract

Three-component olefin difunctionalization represents a powerful strategy for constructing complex organic molecules. However, its advancement has been constrained by persistent challenges in chemoselectivity, environmental sustainability, and cost efficiency. The synergistic integration of cost-effective copper catalysis with radical chemistry offers a promising approach to address these limitations. This review provides a comprehensive analysis of copper-catalyzed, redox-neutral three-component olefin difunctionalization reactions, systematically examining both the diverse reaction types and their underlying mechanisms.