Phenothiazinium as Metal‐Free CH Arylation Reagent for Unactivated Arenes

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-09-26 DOI:10.1002/adsc.70098

Bo Yang , Bai‐Chuan Ding , Zhi‐Ao Tian , Jian‐Ping Qu , Yan‐Biao Kang

引用次数: 0

Abstract

The construction of (hetero)biaryls plays a crucial role in chemical science, with applications in pharmaceuticals, agrochemicals, natural products, and organic materials. While aryl sulfonium salts (aryl thianthrenium‐salts and aryl DBT‐salts) have provided access to (hetero)biaryls, these methods typically require photocatalysts or transition metals to activate the reagents. Herein, a mild, visible light‐mediated, transition metal‐free, and catalyst‐free arylation of arenes using aryl phenothiazinium salts as dual functional reagents is reported. A variety of biaryls and heterobiaryls are obtained in moderate to high yields.

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吩噻嗪作为非活化芳烃的无金属C - H芳基化试剂

杂二芳基的构建在化学科学中起着至关重要的作用，在制药、农用化学品、天然产品和有机材料中都有应用。虽然芳基磺盐（芳基硫鎓盐和芳基DBT盐）提供了获得（杂）双芳基的途径，但这些方法通常需要光催化剂或过渡金属来激活试剂。本文报道了一种温和的、可见光介导的、无过渡金属和无催化剂的芳烃芳基化反应，使用芳基吩噻嗪盐作为双功能试剂。各种双芳基和杂双芳基均可获得中高产率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.