{"title":"Unveiling the potential of dendrobine: insights into bioproduction, bioactivities, safety, circular economy, and future prospects.","authors":"Surendra Sarsaiya, Archana Jain, Fuxing Shu, Qi Jia, Qihai Gong, Qin Wu, Jingshan Shi, Jishuang Chen","doi":"10.1080/07388551.2024.2438161","DOIUrl":null,"url":null,"abstract":"<p><p>This comprehensive review aims to explore and consolidate the current knowledge on dendrobine, including its biological activities, molecular mechanisms of action, effects on various physiological processes, potential toxicity, and safety considerations, in order to unlock its full potential in various applications. Dendrobine has diverse biological effects, including anti-inflammatory, antioxidant, neuroprotective, immunomodulatory, and anticancer effects. Dendrobine also exerts neuroprotective effects by boosting neuronal survival, reducing neuroinflammation, and regulating neurotransmitter release. Dendrobine also has immunomodulatory effects that control immune cell function and modify immunological responses. Dendrobine also exhibits anticancer properties by decreasing tumor angiogenesis and metastasis, causing apoptosis in cancer cells, and inhibiting cancer cell growth. This review also discusses the idea of a circular economy to produce dendrobine, researching cutting-edge and sustainable methods that maximize resource efficiency and reduce environmental effects. Additionally, by supporting circular economy principles for sustainable production and outlining potential future study areas, this discovery will help maximize the use of dendrobine in a variety of applications while preserving its safety and the environment. Future dendrobine research should focus on advancing its application in personalized medicine, exploring green bioproduction methods, and ensuring ethical sourcing practices. An enhanced understanding of its molecular mechanisms and the potential for synergistic therapies could revolutionize healthcare, whereas sustainable production methods and conservation efforts could safeguard its ecological impact.</p>","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":"45 6","pages":"1268-1286"},"PeriodicalIF":7.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/07388551.2024.2438161","RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/6 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This comprehensive review aims to explore and consolidate the current knowledge on dendrobine, including its biological activities, molecular mechanisms of action, effects on various physiological processes, potential toxicity, and safety considerations, in order to unlock its full potential in various applications. Dendrobine has diverse biological effects, including anti-inflammatory, antioxidant, neuroprotective, immunomodulatory, and anticancer effects. Dendrobine also exerts neuroprotective effects by boosting neuronal survival, reducing neuroinflammation, and regulating neurotransmitter release. Dendrobine also has immunomodulatory effects that control immune cell function and modify immunological responses. Dendrobine also exhibits anticancer properties by decreasing tumor angiogenesis and metastasis, causing apoptosis in cancer cells, and inhibiting cancer cell growth. This review also discusses the idea of a circular economy to produce dendrobine, researching cutting-edge and sustainable methods that maximize resource efficiency and reduce environmental effects. Additionally, by supporting circular economy principles for sustainable production and outlining potential future study areas, this discovery will help maximize the use of dendrobine in a variety of applications while preserving its safety and the environment. Future dendrobine research should focus on advancing its application in personalized medicine, exploring green bioproduction methods, and ensuring ethical sourcing practices. An enhanced understanding of its molecular mechanisms and the potential for synergistic therapies could revolutionize healthcare, whereas sustainable production methods and conservation efforts could safeguard its ecological impact.
期刊介绍:
Biotechnological techniques, from fermentation to genetic manipulation, have become increasingly relevant to the food and beverage, fuel production, chemical and pharmaceutical, and waste management industries. Consequently, academic as well as industrial institutions need to keep abreast of the concepts, data, and methodologies evolved by continuing research. This journal provides a forum of critical evaluation of recent and current publications and, periodically, for state-of-the-art reports from various geographic areas around the world. Contributing authors are recognized experts in their fields, and each article is reviewed by an objective expert to ensure accuracy and objectivity of the presentation.