Sulfated tungstate: an eco-friendly and reusable catalyst for efficient one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones in solvent-free conditions

Abstract

A straightforward, one-pot, solvent-free, and environmentally friendly method for synthesizing 4,6-Diarylpyrimidin-2(1H)-ones through a Biginelli-type reaction is presented, utilizing sulfated tungstate as a catalyst. This approach offers enhanced product yields while employing a cost-effective and easily accessible catalyst. The simplicity of the experimental setup makes it an effective and stress-free strategy for producing 4,6-diarylpyrimidin-2-(1H)-ones. The catalyst demonstrates remarkable activity and can be reused, further contributing to the method’s efficiency.