Frontoparietal network activity during a combined action observation and proprioceptive stimulation protocol reveals long-term plasticity in the primary motor cortex

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-08-25 DOI:10.1016/j.neuroimage.2025.121432

Ambra Bisio , Costanza Iester , Monica Biggio , Laura Avanzino , Sabrina Brigadoi , Simone Cutini , Laura Bonzano , Marco Bove

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引用次数: 0

Abstract

The aim of this study was to investigate changes in cortical hemodynamic activity within a frontoparietal network during the administration of an innovative action observation (AO) and proprioceptive stimulation (PS) protocol, and to examine whether this activity could predict the efficacy of the protocol in evoking M1 plasticity, reflected in significant long-term changes in M1 excitability. AO-PS was composed of 50 bursts of combined stimuli. Each burst consisted of five couples of AO and PS during which participants observed a video showing thumb opposition movements and simultaneously received a mechanical vibration on the extensor pollicis brevis muscle (stimulation frequency 80 Hz). During AO-PS, the hemodynamic activity was measured by means of functional Near-Infrared Spectroscopy. Recruitment curves were assessed using transcranial magnetic stimulation before, immediately, 30 and 60 min after AO-PS, to evaluate changes in M1 excitability. During AO-PS, a significant increase in oxyhemoglobin (HbO) concentration changes was found in the following Brodmann Areas (BA): left and right BA6, BA44, and BA43, left BA3, BA4, BA40 and BA7. The highest increment was found in the left BA4. In left BA7 and BA40 the time-to-peak in HbO concentration changes were reached significantly later than in the other BAs. On average, no significant changes were observed after AO-PS administration in M1 excitability, but HbO concentration changes in the left BA7 correlated with plasticity index. These findings highlight the involvement of sensorimotor and associative fronto-parietal regions during AO-PS. Additionally, the activity of the left BA7 revealed the plasticity induced by AO-PS in M1.

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在联合动作观察和本体感觉刺激方案中，额顶叶网络活动揭示了初级运动皮层的长期可塑性

本研究的目的是研究在创新动作观察（AO）和本体感觉刺激（PS）方案中额顶叶网络皮层血流动力学活动的变化，并研究这种活动是否可以预测方案在唤起M1可塑性方面的有效性，这反映在M1兴奋性的显著长期变化上。AO-PS由50次联合刺激组成。每次爆发包括五对AO和PS，在此期间，参与者观察拇指对立运动的视频，同时在拇短伸肌上接受机械振动（刺激频率80 Hz）。在AO-PS过程中，用功能近红外光谱法测定血流动力学活性。在AO-PS前、即刻、30 min和60 min采用经颅磁刺激评估招募曲线，评估M1兴奋性的变化。AO-PS期间，在左、右BA6、BA44、BA43区，左BA3、BA4、BA40、BA7区，血氧蛋白（HbO）浓度变化显著升高。左侧BA4的增量最大。左侧BA7和BA40的HbO浓度变化达到峰值的时间明显晚于其他ba。平均而言，给药后M1兴奋性无明显变化，但左BA7 HbO浓度变化与可塑性指数相关。这些发现强调了在AO-PS过程中感觉运动和联合额顶叶区域的参与。此外，左BA7的活性揭示了AO-PS在M1中诱导的可塑性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.