In vivo analysis of age-related changes in longitudinal modulus and morphology of the crystalline lens: A combined Brillouin optical scanning and OCT study

IF 2.7 2区医学 Q1 OPHTHALMOLOGY

Experimental eye research Pub Date : 2025-08-19 DOI:10.1016/j.exer.2025.110591

Fen Song , Le Chang , Shijia Qu , Shaohu Bai , Yan Wang

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Abstract

Purpose

To explore the correlation between age and in vivo parameters such as the longitudinal modulus of the lens nucleus (LMN), anterior cortex (LMAC), posterior cortex (LMPC), and lens morphology in healthy adults.

Methods

A total of 191 right eyes of healthy adults (18–67 years) were included. General demographic information was collected, and Brillouin optical scanning and optical coherence tomography imaging were performed. Correlation and multiple regression analyses were conducted to analyze the factors associated with the lens longitudinal modulus and other parameters. Principal component analysis (PCA) was performed to investigate the relationships between the lens morphological and longitudinal modulus parameters and age.

Results

The LMN was positively correlated with age (β = 0.304, P = 0.044), whereas the LMAC and LMPC showed no correlation with age (P > 0.05). The LMN, LMAC, and LMPC were negatively correlated with lens density (LD) (β = −0.794, P < 0.001; β = −0.273, P = 0.033; β = −0.422, P = 0.001). Moreover, the LMN was higher in females than in males (β = 0.159, P = 0.009). PCA revealed that age had greater influence on morphological parameters than on longitudinal modulus parameters (morphological PC1: R² = 0.469 vs. longitudinal modulus PC1: R² = 0.181).

Conclusions

Changes in lens morphological parameters in vivo were more closely correlated with age than were its longitudinal modulus parameters. The LMN increased with age, and LD was a key factor influencing the longitudinal modulus.

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晶体纵向模量和形态随年龄变化的体内分析：布里渊光学扫描和OCT联合研究

目的探讨健康成人晶状体核纵向模量（LMN）、晶状体前皮质（LMAC）、晶状体后皮质（LMPC）及晶状体形态等体内参数与年龄的关系。方法选取18 ~ 67岁健康成人191只右眼。收集一般人口统计信息，进行布里渊光学扫描和光学相干层析成像。通过相关分析和多元回归分析，分析影响晶状体纵向模量等参数的因素。采用主成分分析（PCA）研究晶状体形态和纵向模量参数与年龄的关系。结果LMN与年龄呈正相关（β = 0.304, P = 0.044）， LMAC、LMPC与年龄无相关性（P > 0.05）。LMN、LMAC和LMPC与晶状体密度（LD）呈负相关（β = - 0.794, P < 0.001; β = - 0.273, P = 0.033; β = - 0.422, P = 0.001）。女性的LMN高于男性（β = 0.159, P = 0.009）。年龄对形态参数的影响大于对纵向模量参数的影响（形态PC1: R2 = 0.469 vs纵向模量PC1: R2 = 0.181）。结论活体晶状体形态参数的变化与年龄的关系比晶状体纵向模量参数的变化更密切。LMN随龄期增加而增加，LD是影响纵向模量的关键因素。

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来源期刊

Experimental eye research 医学-眼科学

CiteScore

6.80

自引率

5.90%

发文量

323

审稿时长

66 days

期刊介绍： The primary goal of Experimental Eye Research is to publish original research papers on all aspects of experimental biology of the eye and ocular tissues that seek to define the mechanisms of normal function and/or disease. Studies of ocular tissues that encompass the disciplines of cell biology, developmental biology, genetics, molecular biology, physiology, biochemistry, biophysics, immunology or microbiology are most welcomed. Manuscripts that are purely clinical or in a surgical area of ophthalmology are not appropriate for submission to Experimental Eye Research and if received will be returned without review.