End of the line: a kinetic ruler model for poly(A) tail termination

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-08-26 DOI:10.1101/gad.353241.125

Anita H. Corbett

引用次数: 0

Abstract

Polyadenylation of mRNA is a key step in post-transcriptional regulation. In this issue of Genes & Development, Gabs and colleagues (doi:10.1101/gad.352912.125) provide evidence for a novel, kinetically driven mechanism that dictates the length of poly(A) tails added to mRNAs in budding yeast. The investigators introduce the concept of Nab2, a zinc finger poly(A) RNA binding protein, as a “kinetic ruler,” which functions through dynamic competition with the cleavage and polyadenylation complex (CPAC) to define the length of poly(A) tails.

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终点线：poly(a)尾部终止的动力学尺子模型

mRNA的聚腺苷化是转录后调控的关键步骤。在这一期的《基因与发育》中，Gabs和他的同事（doi:10.1101/gad.352912.125）提供了一种新的动力学驱动机制的证据，该机制决定了出芽酵母中加入mrna的多聚(a)尾部的长度。研究人员介绍了锌指聚(a) RNA结合蛋白Nab2的概念，作为“动力学标尺”，它通过与切割和聚腺苷化复合体（CPAC）的动态竞争来定义聚(a)尾部的长度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).